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Clinical Manifestations.
Narueporn Pagowong1,2,3, Kanokphong Suparan1,2,4, Chanon Kunasol1,2,3
1Center of Excellence in Cardiac Electrophysiology Research, Chiang Mai University, Chiang Mai, Thailand.
Alzheimer'S & Dementia : the Journal of the Alzheimer'S Association
|December 25, 2025
Summary
Recent acute coronary syndrome (ACS) patients show gut dysbiosis and cognitive decline. Specific gut bacteria like Peptostreptococcus may indicate cognitive impairment in ACS survivors.
Area of Science:
- Microbiome research
- Cardiovascular medicine
- Neuroscience
Background:
- Gut dysbiosis is linked to cognitive impairments and acute coronary syndrome (ACS).
- The relationship between gut microbiota and cognitive function in recent ACS patients is not well understood.
Purpose of the Study:
- Investigate gut microbiota composition and cognitive function in recent ACS patients.
- Compare gut microbiota and cognitive outcomes between ACS patients and high cardiovascular risk controls.
Main Methods:
- Enrolled 50 ACS patients and 42 high cardiovascular risk controls.
- Assessed neurocognitive function using the Montreal Cognitive Assessment (MoCA).
- Analyzed gut microbiome composition via 16S rRNA sequencing of fecal samples.
Main Results:
- ACS patients exhibited significantly lower MoCA scores and cognitive function across all domains compared to controls.
- ACS patients showed gut dysbiosis with altered microbial diversity and composition, including increased Firmicutes/Bacteroidota and Enterobacteriaceae/Proteobacteria ratios.
- A negative correlation was found between specific gut taxa (Peptostreptococcales-Tissierellales, Peptostreptococcus) and MoCA scores in ACS patients.
Conclusions:
- Alterations in gut microbiota are associated with cognitive impairments in recent ACS patients.
- Peptostreptococcales-Tissierellales and Peptostreptococcus may serve as potential biomarkers for cognitive impairment in ACS patients.
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