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Related Concept Videos

Blood Studies for Cardiovascular System I: Cardiac Biomarkers01:20

Blood Studies for Cardiovascular System I: Cardiac Biomarkers

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Cardiac biomarkers are enzymes, proteins, and hormones released into the blood when cardiac cells are injured. They are powerful tools for triaging.
The essential diagnostic tools for detecting myocardial necrosis and monitoring individuals suspected of having acute coronary syndrome (ACS) include:
Troponins
Troponins, particularly cardiac troponins I and T, are the most precise and sensitive markers of myocardial injury. They are detectable within 4-6 hours of myocardial injury and remain...
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Blood Studies for Cardiovascular System II: CRP, Hcy, and Cardiac Natriuretic Peptide Markers01:19

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Cardiac biomarkers are critical in diagnosing, prognosing, and managing cardiovascular diseases. Routine measurement of specific biomarkers such as B-type natriuretic peptide (BNP), C-reactive protein (CRP), and homocysteine (Hcy) is common practice in clinical settings to evaluate heart function and predict cardiovascular events.
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Cardiac myocytes produce these hormones in response to ventricular stretching...
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Related Experiment Video

Updated: Jan 7, 2026

Dried Blood Spot Collection of Health Biomarkers to Maximize Participation in Population Studies
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Biomarkers.

Brianne A Kent1, Mayuko Arai1

  • 1Simon Fraser University, Vancouver, BC, Canada.

Alzheimer'S & Dementia : the Journal of the Alzheimer'S Association
|December 25, 2025
PubMed
Summary
This summary is machine-generated.

Trazodone enhances slow-wave sleep and reduces Alzheimer's disease (AD) neuropathology, particularly amyloid plaques in male mice. This suggests trazodone may be a disease-modifying therapeutic for AD.

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Area of Science:

  • Neuroscience
  • Pharmacology
  • Gerontology

Background:

  • Sleep disturbances, including reduced slow-wave sleep (SWS), are common in Alzheimer's disease (AD).
  • Restoring SWS is a potential strategy to slow AD progression.
  • Trazodone, an antidepressant, enhances SWS and is well-tolerated in the elderly.

Purpose of the Study:

  • To evaluate the effects of chronic trazodone administration in a mouse model of AD.
  • To assess trazodone's potential as a disease-modifying therapeutic for AD beyond its sleep-promoting effects.

Main Methods:

  • Developed a translational trazodone administration paradigm in C57BL/6J mice.
  • Administered trazodone (60mg/kg) daily to APP NL-F mice at early (9 months) and intermediate (14 months) disease stages for up to 60 days.
  • Evaluated effects on EEG power spectra, behavior/cognition, and neuropathology.

Main Results:

  • Trazodone consistently enhanced slow oscillation and delta power during NREM sleep over 60 days.
  • Trazodone treatment reduced amyloid-beta (Aβ) pathologies in male APP NL-F mice.
  • Significant reductions observed in amyloid plaques and fibrillary plaques in male mice treated from 14 to 16 months of age.

Conclusions:

  • Trazodone demonstrates potential as a disease-modifying therapeutic for Alzheimer's disease.
  • Further exploration of trazodone for AD treatment is warranted based on these findings.