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Clinical Manifestations.

Christian Loveland1, Estevao Ribeiro1, Scott Roye1

  • 1University of Oklahoma Health Sciences Center, Oklahoma City, OK, USA.

Alzheimer'S & Dementia : the Journal of the Alzheimer'S Association
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Summary
This summary is machine-generated.

This study presents a rare case of apraxia of eyelid closure (AEC) in a patient with corticobasal syndrome (CBS). The findings suggest AEC can occur in neurodegenerative conditions like corticobasal degeneration (CBD), highlighting the need for further research.

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Area of Science:

  • Neuroscience
  • Neurology

Background:

  • Eyelid apraxias, including apraxia of eyelid opening (AEO) and the rarer apraxia of eyelid closure (AEC), involve difficulties with voluntary eyelid movements.
  • Corticobasal syndrome (CBS) is a progressive neurodegenerative disorder often associated with primary tauopathies like corticobasal degeneration (CBD).
  • While AEO is recognized in CBS, AEC is less common, presenting a unique clinical challenge.

Purpose of the Study:

  • To report a case of corticobasal syndrome (CBS) presenting with apraxia of eyelid closure (AEC).
  • To discuss the potential underlying pathophysiology and neuroanatomical correlates of AEC within the context of CBS.
  • To contribute to the understanding of rare movement disorders in neurodegenerative diseases.

Main Methods:

  • A case report detailing a 72-year-old woman with a 5-year history of neurological symptoms including speech difficulties, parkinsonism, and apraxia.
  • Neurological examination revealed apraxia of speech and apraxia of eyelid closure (AEC) with preserved reflex blinking.
  • Brain MRI showed mild bifrontal and right-sided atrophy; DaT-scan was negative.

Main Results:

  • The patient met criteria for possible corticobasal syndrome (CBS), with clinical presentation and atrophy patterns suggesting a 4R-tauopathy, such as corticobasal degeneration (CBD).
  • Apraxia of eyelid closure (AEC) was a prominent feature, occurring alongside other CBS symptoms.
  • Neuropsychological testing indicated global cognitive impairment, with specific deficits in speech and motor control.

Conclusions:

  • Apraxia of eyelid closure (AEC) is a rare condition that can manifest in neurodegenerative disorders, including primary tauopathies like corticobasal degeneration (CBD).
  • The findings support the association of AEC with 4R-tauopathies and suggest potential involvement of insular and frontoparietal networks.
  • Further research is necessary to elucidate the lesion network of AEC and its relationship with language networks in neurodegenerative diseases.