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Cardiac biomarkers are enzymes, proteins, and hormones released into the blood when cardiac cells are injured. They are powerful tools for triaging.
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Dried Blood Spot Collection of Health Biomarkers to Maximize Participation in Population Studies
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Biomarkers.

Jocelyn Jaen1, Konstantinos Arfanakis1,2,3, Yingjuan Wu1,3

  • 1Rush Alzheimer's Disease Center, Chicago, IL, USA.

Alzheimer'S & Dementia : the Journal of the Alzheimer'S Association
|December 25, 2025
PubMed
Summary
This summary is machine-generated.

MRI-derived brain age clocks show promise for assessing brain health in older Latinos. These clocks correlate with chronological age and cognitive function, suggesting their utility as biomarkers in this population.

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Area of Science:

  • Neuroimaging
  • Biomarkers
  • Gerontology

Background:

  • MRI-derived brain age clocks are valuable biomarkers for brain health.
  • Current clocks have limited application in diverse populations.
  • This study evaluated an MRI-derived clock in a Latino cohort due to high rates of neurological diseases.

Purpose of the Study:

  • To calculate and evaluate the Simple Fully Convolutional Networks regression variant (SFCN-reg) MRI-derived biological clock using neuroimaging data from a Latino cohort.
  • To assess the performance of the SFCN-reg clock in relation to chronological age and cognitive function in older Latinos.

Main Methods:

  • Structural neuroimaging and cognitive data from 125 older Latinos (mean age 74) were analyzed.
  • The SFCN-reg clock was calculated, and a fine-tuned version was developed.
  • Correlations with chronological age and associations with global and domain-specific cognitive scores were examined using linear mixed effects models.

Main Results:

  • The SFCN-reg clocks showed strong correlations with chronological age (r=0.73 for original, r=0.70 for fine-tuned).
  • Increased SFCN-reg brain age was associated with reduced global cognitive scores.
  • Both clock versions predicted faster cognitive decline over time.

Conclusions:

  • SFCN-reg brain age clocks demonstrated good performance in an older Latino cohort, correlating with age and cognition.
  • These clocks show potential as biomarkers for brain health in Latino populations.
  • Further research with larger Latino samples is recommended to validate these findings.