Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Chronic Kidney Disease II: Clinical Manifestations01:24

Chronic Kidney Disease II: Clinical Manifestations

520
Chronic Kidney Disease (CKD) progressively impairs multiple body systems due to the accumulation of uremic toxins, which disrupt cellular functions across various organs.Neurologic symptomsNeurologic symptoms often arise early in CKD, as uremic toxin buildup drives changes in cognitive and motor functions. Patients frequently experience fatigue, headache, confusion, difficulty concentrating, and, in severe cases, seizures. Peripheral neuropathy commonly manifests as burning sensations in the...
520
Coronary Artery Disease III: Clinical Manifestations01:30

Coronary Artery Disease III: Clinical Manifestations

299
Coronary Artery Disease (CAD) is a primary health risk worldwide, leading to significant morbidity and mortality. The condition arises from the buildup of atherosclerotic plaques within the coronary arteries, resulting in diminished blood supply to the heart muscle.The clinical manifestations of CAD vary widely, from asymptomatic stages to severe, life-threatening conditions. Understanding these manifestations is crucial for early diagnosis and effective management.Angina Pectoris: The Warning...
299
Endocarditis II: Clinical Features of Infective Endocarditis01:25

Endocarditis II: Clinical Features of Infective Endocarditis

364
Endocarditis can present various clinical features depending on the causative organism and the patient's underlying health conditions. Initially, the clinical features of infective endocarditis develop gradually, presenting with nonspecific symptoms that can be easily mistaken for other illnesses.General SymptomsEarly symptoms of infective endocarditis are fever, chills, weakness, malaise, fatigue, and weight loss. These symptoms reflect the systemic nature of the infection and the body's...
364
Heart Failure III: Clinical Manifestations01:26

Heart Failure III: Clinical Manifestations

436
Heart failure (HF) manifests primarily as dyspnea, fatigue, and fluid retention, resulting in peripheral and pulmonary edema. Symptoms may vary depending on which ventricle is more affected, left or right.Left-Sided Heart FailureAlso known as left ventricular failure, this condition results from the left ventricle's inability to fill or eject sufficient blood into the systemic circulation. It leads to pulmonary congestion, which occurs when the left ventricle fails to eject blood effectively...
436
Gastroesophageal Reflux Disease II: Clinical Features and Management01:29

Gastroesophageal Reflux Disease II: Clinical Features and Management

652
Gastroesophageal reflux disease, or GERD, is a persistent medical condition that affects many individuals worldwide. Its clinical manifestations can vary greatly, making diagnosis and management challenging for healthcare professionals. The following is a comprehensive overview of the clinical manifestations, assessment, and management strategies for GERD.
Clinical Manifestations
GERD presents itself in a multitude of ways, with symptoms varying from person to person. The hallmark symptoms are...
652
Hypertension III: Clinical Manifestations and Diagnostic Studies01:30

Hypertension III: Clinical Manifestations and Diagnostic Studies

437
Hypertension is asymptomatic and also referred to as the "silent killer" until it progresses to a severe stage or causes target organ disease. Patients may experience symptoms stemming from the strain on blood vessels and tissues in various organs or the heart's increased workload.Physical exams might show no abnormalities other than high blood pressure. Signs of vascular damage, when present, correspond to the organs supplied by the affected vessels, leading to target organ damage. For...
437

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Tumor Mutation Signature Reveals the Risk Factors of Lung Adenocarcinoma with <i>EGFR</i> or <i>KRAS</i> Mutation.

Cancer control : journal of the Moffitt Cancer Center·2025
Same author

A comprehensive analysis of vasculogenic mimicry related genes to predict the survival rate of HCC and its influence on the tumor microenvironment.

Frontiers in genetics·2025
Same author

Identification and knockout of rhamnose synthase CiRHM1 enhances accumulation of flavone aglycones in chrysanthemum flower.

Plant biotechnology journal·2024
Same author

Constructing Quasi-Localized High-Concentration Solvation Structures to Stabilize Battery Interfaces in Nonflammable Phosphate-Based Electrolyte.

Advanced science (Weinheim, Baden-Wurttemberg, Germany)·2024
Same author

Low- and Intermediate-Grade Lateral Sinus Dural Arteriovenous Fistulas: Factors Affecting the Outcome of Endovascular Treatment over 18-Year Experience in a High-Volume Neurovascular Center.

AJNR. American journal of neuroradiology·2024
Same author

The Manipulation of Ring-Open Polymerization Process to Boost the Electrochemical Performance for Solid-State Lithium Metal Batteries.

ChemSusChem·2024
Same journal

Breaking barriers: Enhancing access to dementia clinical trials in the United Kingdom-Insights from the Scientific Advisory Board of the Dame Barbara Windsor Dementia Goals Programme.

Alzheimer's & dementia : the journal of the Alzheimer's Association·2026
Same journal

Unveiling the procoagulant state in Alzheimer's disease: A novel PET imaging strategy.

Alzheimer's & dementia : the journal of the Alzheimer's Association·2026
Same journal

Estimated labor market outcomes of people progressing from preclinical to early-stage Alzheimer's disease in the United States.

Alzheimer's & dementia : the journal of the Alzheimer's Association·2026
Same journal

Amyloid exacerbates tau and alpha-synuclein pathologies, behavioral impairments, and neuroinflammation in a mixed dementia model.

Alzheimer's & dementia : the journal of the Alzheimer's Association·2026
Same journal

Multimorbidity burden and patterns associated with DeepBrainNet-derived brain-age gap in dementia-free older adults: A community-based study.

Alzheimer's & dementia : the journal of the Alzheimer's Association·2026
Same journal

Reply to "Shifting the emphasis of brain health literacy from individuals to systems to reduce inequalities".

Alzheimer's & dementia : the journal of the Alzheimer's Association·2026
See all related articles

Related Experiment Video

Updated: Jan 7, 2026

A Metadata Extraction Approach for Clinical Case Reports to Enable Advanced Understanding of Biomedical Concepts
07:50

A Metadata Extraction Approach for Clinical Case Reports to Enable Advanced Understanding of Biomedical Concepts

Published on: September 20, 2018

16.4K

Clinical Manifestations.

Wenkui Xiong1, Zhen Gu2, Bo Hong1

  • 1Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai, China.

Alzheimer'S & Dementia : the Journal of the Alzheimer'S Association
|December 25, 2025
PubMed
Summary
This summary is machine-generated.

The Spatial Memory Test (SMT) effectively detects mild cognitive impairment (MCI) in older adults. This digital assessment shows promise for early dementia screening in community settings.

More Related Videos

Imaging Features of Systemic Sclerosis-Associated Interstitial Lung Disease
04:44

Imaging Features of Systemic Sclerosis-Associated Interstitial Lung Disease

Published on: June 16, 2020

20.7K
Isolating Human Peripheral Blood Mononuclear Cells and CD4+ T cells from S&#233;zary Syndrome Patients for Transcriptomic Profiling
09:08

Isolating Human Peripheral Blood Mononuclear Cells and CD4+ T cells from Sézary Syndrome Patients for Transcriptomic Profiling

Published on: October 14, 2021

6.1K

Related Experiment Videos

Last Updated: Jan 7, 2026

A Metadata Extraction Approach for Clinical Case Reports to Enable Advanced Understanding of Biomedical Concepts
07:50

A Metadata Extraction Approach for Clinical Case Reports to Enable Advanced Understanding of Biomedical Concepts

Published on: September 20, 2018

16.4K
Imaging Features of Systemic Sclerosis-Associated Interstitial Lung Disease
04:44

Imaging Features of Systemic Sclerosis-Associated Interstitial Lung Disease

Published on: June 16, 2020

20.7K
Isolating Human Peripheral Blood Mononuclear Cells and CD4+ T cells from S&#233;zary Syndrome Patients for Transcriptomic Profiling
09:08

Isolating Human Peripheral Blood Mononuclear Cells and CD4+ T cells from Sézary Syndrome Patients for Transcriptomic Profiling

Published on: October 14, 2021

6.1K

Area of Science:

  • Gerontology
  • Neuroscience
  • Cognitive Psychology

Background:

  • Mild cognitive impairment (MCI) is a critical transitional stage between normal aging and dementia.
  • Early detection of MCI is vital for timely intervention and dementia prevention.
  • The Spatial Memory Test (SMT), utilizing Four Mountains Test (4MT) technology, assesses visuospatial abilities and may indicate early cognitive decline.

Purpose of the Study:

  • To investigate the diagnostic utility of the Spatial Memory Test (SMT) for identifying mild cognitive impairment (MCI) in a community-based elderly cohort.
  • To evaluate the SMT's ability to differentiate between normal cognition and MCI.
  • To explore the correlation between SMT performance and other established neuropsychological tests.

Main Methods:

  • A cohort of 336 elderly individuals from the Shanghai Brain Aging Study was divided into Normal Cognition (NC) and MCI groups.
  • SMT scores were compared between the NC and MCI groups.
  • Regression analysis was employed to assess the diagnostic accuracy of SMT scores for MCI, controlling for demographic factors.

Main Results:

  • Individuals in the NC group achieved significantly higher SMT scores compared to the MCI group (9.95±1.74 vs. 6.38±1.93, p < 0.001).
  • SMT performance correlated significantly with multiple neuropsychological tests, including memory, executive function, and processing speed (p < 0.001).
  • The SMT demonstrated excellent predictive ability for MCI, with an Area Under the Curve (AUC) of 0.923 (p < 0.001) after adjusting for age, gender, and education.

Conclusions:

  • The Spatial Memory Test (SMT) shows strong potential for detecting mild cognitive impairment (MCI).
  • SMT performance reflects various cognitive domains, suggesting its comprehensive assessment capabilities.
  • A diagnostic model based on SMT could serve as a valuable tool for screening cognitive impairment and facilitating early dementia detection in community-dwelling elderly populations.