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A Metadata Extraction Approach for Clinical Case Reports to Enable Advanced Understanding of Biomedical Concepts
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Clinical Manifestations.

Kiirtaara Aravindhan1, Yi Jin Leow2, Pricilia Tanoto3

  • 1Lee Kong Chian School of Medicine, Nanyang Technological University, Singapore, Singapore.

Alzheimer'S & Dementia : the Journal of the Alzheimer'S Association
|December 25, 2025
PubMed
Summary
This summary is machine-generated.

Mild behavioral impairment (MBI) is linked to physical frailty in older adults with mixed dementia pathologies. Worse MBI scores increase the likelihood of prefrailty, suggesting a behavioral component in cognitive decline.

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Area of Science:

  • Neurology
  • Gerontology
  • Behavioral Science

Background:

  • Mild behavioral impairment (MBI) and physical frailty are common in older adults, often preceding dementia.
  • The link between MBI, frailty, and underlying pathologies like amyloid-beta (Aß) and cerebrovascular disease is understudied.
  • This research investigates MBI and frailty associations in a Southeast Asian cohort at risk for dementia due to Aß and/or cerebrovascular pathology.

Purpose of the Study:

  • To examine the association between MBI and physical frailty in individuals at symptomatic risk for dementia.
  • To explore these associations in relation to underlying amyloid-beta and/or cerebrovascular pathology.
  • To identify potential behavioral markers for cognitive impairment risk.

Main Methods:

  • A cross-sectional study of 293 community-dwelling adults with subjective cognitive decline or mild cognitive impairment.
  • MBI assessed using the Mild Behavioral Impairment Checklist (MBI-C); physical frailty by Fried Frailty Phenotype.
  • Pathology determined by plasma Aß42/40 ratio (Aß) and modified Fazekas rating (cerebrovascular); participants categorized into pure-Aß or mixed pathology groups.

Main Results:

  • In the mixed pathology group, prefrail individuals showed significantly lower MBI-C scores in mood, impulse, and belief domains compared to non-frail individuals.
  • No significant differences in MBI-C scores were found between non-frail and prefrail individuals in the pure-Aß pathology group.
  • Increased MBI-C total score and specific domains (mood, impulse, belief) were significantly associated with a higher likelihood of being prefrail in the mixed pathology group, even after adjustments.

Conclusions:

  • A significant association exists between MBI and frailty in individuals with mixed vascular-amyloid pathology.
  • Worsening MBI symptoms correlate with an increased likelihood of prefrailty in this population.
  • These findings suggest a behavioral component in the progression of cognitive impairment, meriting further investigation for early detection and intervention strategies.