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Related Concept Videos

Blood Studies for Cardiovascular System I: Cardiac Biomarkers01:20

Blood Studies for Cardiovascular System I: Cardiac Biomarkers

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Cardiac biomarkers are enzymes, proteins, and hormones released into the blood when cardiac cells are injured. They are powerful tools for triaging.
The essential diagnostic tools for detecting myocardial necrosis and monitoring individuals suspected of having acute coronary syndrome (ACS) include:
Troponins
Troponins, particularly cardiac troponins I and T, are the most precise and sensitive markers of myocardial injury. They are detectable within 4-6 hours of myocardial injury and remain...
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Blood Studies for Cardiovascular System II: CRP, Hcy, and Cardiac Natriuretic Peptide Markers01:19

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Cardiac biomarkers are critical in diagnosing, prognosing, and managing cardiovascular diseases. Routine measurement of specific biomarkers such as B-type natriuretic peptide (BNP), C-reactive protein (CRP), and homocysteine (Hcy) is common practice in clinical settings to evaluate heart function and predict cardiovascular events.
These markers indicate stress or strain on the heart muscle:
Natriuretic Peptides (BNP)
Cardiac myocytes produce these hormones in response to ventricular stretching...
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Related Experiment Video

Updated: Jan 7, 2026

Dried Blood Spot Collection of Health Biomarkers to Maximize Participation in Population Studies
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Biomarkers.

Tianyi Wang1, Yuyue Qiu1, Li Shang1

  • 1Peking Union Medical College Hospital, Beijing, Beijing, China.

Alzheimer'S & Dementia : the Journal of the Alzheimer'S Association
|December 25, 2025
PubMed
Summary
This summary is machine-generated.

Plasma pTau217 levels effectively distinguish Alzheimer's disease (AD) from other neurodegenerative dementias. This blood biomarker shows diagnostic accuracy comparable to cerebrospinal fluid (CSF) and PET imaging.

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Area of Science:

  • Neuroscience
  • Biomarker Discovery
  • Diagnostic Accuracy

Background:

  • Distinguishing Alzheimer's disease (AD) from other neurodegenerative dementias is clinically challenging.
  • Plasma biomarkers offer a less invasive alternative to traditional diagnostic methods like CSF analysis and PET imaging.
  • Evaluating the diagnostic efficacy of various plasma biomarkers is crucial for early and accurate AD diagnosis.

Purpose of the Study:

  • To assess the diagnostic performance of plasma biomarkers in differentiating AD from other neurodegenerative conditions.
  • To compare the efficacy of SIMOA and Lumipulse detection methods for blood biomarker measurement.
  • To determine if plasma biomarkers can predict AD pathology with accuracy comparable to established methods.

Main Methods:

  • Recruitment of 292 patients from a hospital dementia cohort with diverse diagnoses including AD, CAA, CJD, FTD, HDLS, NIID, NPH, VAD, and undetermined etiology.
  • Measurement of plasma biomarkers (Aβ42/40, pTau181, pTau217, GFAP, NFL) using SIMOA and Lumipulse kits.
  • Statistical comparison of biomarker levels across diagnostic groups and correlation with CSF and PET imaging results.

Main Results:

  • Plasma pTau217 demonstrated the most significant difference between AD and other neurodegenerative diseases.
  • Elevated plasma pTau217 levels were observed in specific conditions like CAA and CJD, comparable to AD.
  • Plasma pTau217 accurately predicted CSF Aβ status (accuracy >0.9) and Aβ PET/tau PET classifications (accuracy up to 0.977).
  • Strong correlations were found between SIMOA and Lumipulse measurements for all biomarkers, especially pTau217.

Conclusions:

  • Plasma pTau217 is a highly effective biomarker for differentiating AD pathology in dementia patients.
  • The diagnostic accuracy of plasma pTau217 is comparable to cerebrospinal fluid (CSF) biomarkers and positron emission tomography (PET) imaging.
  • Blood-based pTau217 offers a promising, minimally invasive tool for AD diagnosis and management.