Frequency and Clinical Outcomes of Respiratory Infections in Children with Cancer Presenting with Febrile Illness
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View abstract on PubMed
Summary
This summary is machine-generated.Fever in pediatric cancer patients often lacks a clear source, with respiratory pathogens identified in 70% of cases. Molecular diagnostics can improve fever management and reduce unnecessary antibiotic use in these vulnerable children.
Area Of Science
- Pediatric Oncology
- Infectious Diseases
- Molecular Diagnostics
Background
- Fever is a common complication in pediatric cancer patients undergoing chemotherapy.
- Prompt antibiotic treatment is crucial, but fever sources remain unidentified in many cases.
- Molecular diagnostics offer potential for improved management and reduced antibiotic overuse.
Purpose Of The Study
- To evaluate the pathogenic etiology of febrile episodes in pediatric cancer patients.
- To analyze the clinical characteristics and outcomes of these febrile episodes.
- To assess the utility of molecular diagnostics in identifying fever sources.
Main Methods
- Prospective observational study conducted from January 2019 to March 2020.
- Inclusion of pediatric cancer patients experiencing febrile episodes with or without neutropenia.
- Utilized nasopharyngeal swabs for pathogen detection.
Main Results
- Forty febrile episodes were analyzed in 27 patients (mean age 5 years).
- Respiratory pathogens were detected in 70% of afebrile episodes without a clear focus.
- Rhinovirus was the most common isolate, followed by Streptococcus pneumoniae.
Conclusions
- Respiratory pathogens are frequently identified in febrile episodes without a focus in pediatric cancer patients.
- Molecular diagnostics enhance sensitivity for pathogen detection.
- Individualized management of febrile illness in these children is facilitated by advanced diagnostics.
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