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Brain Imaging

Brain Imaging

Brain imaging technologies provide critical insights into both the structure and function of the human brain, enabling medical professionals and researchers to diagnose, study, and treat neurological disorders or psychiatric disorders more effectively.
These technologies include computerized axial tomography (CAT or CT scans), positron-emission tomography (PET scans), magnetic resonance imaging (MRI), functional magnetic resonance imaging (fMRI), and Transcranial Magnetic...

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Updated: Jan 7, 2026

Whole-brain Segmentation and Change-point Analysis of Anatomical Brain MRI—Application in Premanifest Huntington's Disease

Whole-brain Segmentation and Change-point Analysis of Anatomical Brain MRI—Application in Premanifest Huntington's Disease

Published on: June 9, 2018

Cortical microstructural changes in schizophrenia spectrum disorders using quantitative T1 mapping.

George Nader^1,2, Kimberly L Desmond^1,3,4,5, Matisse Ducharme^1,2

¹Centre for Addiction and Mental Health (CAMH), Toronto, ON, Canada.

Frontiers in Psychiatry

|December 25, 2025

Summary

This summary is machine-generated.

Schizophrenia spectrum disorders (SSD) show altered brain myelination, particularly in frontal and temporal regions. Quantitative T1 imaging revealed increased qT1 values in SSD patients, suggesting impaired myelination, with sex-specific differences observed.

Keywords:

MRI multimodal imaging neuroimaging neuropsychiatry quantitative T1 mapping schizophrenia

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Diffusion Tensor Magnetic Resonance Imaging in the Analysis of Neurodegenerative Diseases

Diffusion Tensor Magnetic Resonance Imaging in the Analysis of Neurodegenerative Diseases

Published on: July 28, 2013

Area of Science:

Neuroimaging
Psychiatry
Neuroscience

Background:

Schizophrenia spectrum disorders (SSD) are associated with cortical brain changes, primarily in frontal and temporal regions.
Previous research focused on macrostructural changes, neglecting microstructural properties like myelination.

Purpose of the Study:

To investigate microstructural cortical changes in SSD using quantitative T1 imaging (qT1).
To assess myelination differences between SSD patients and healthy controls.
To evaluate the impact of different qT1 acquisition sequences and sex on findings.

Main Methods:

Quantitative T1 imaging (qT1) was performed on 14 SSD patients and 7 healthy controls.
Two qT1 acquisition sequences were used: single-echo and multi-echo.
Statistical analyses controlled for age and sex.

Main Results:

SSD patients exhibited increased qT1 values in frontal and temporal areas compared to controls, detected only by the single-echo sequence.
The single-echo qT1 showed a negative correlation with sex in the SSD group, with females having lower qT1 values.
Inter-protocol reliability remains a concern despite quantitative approaches.

Conclusions:

Findings suggest impaired myelination in the frontal and temporal cortices of individuals with SSD.
The choice of qT1 acquisition protocol is critical for detecting these microstructural alterations.
Sex-specific differences in myelination may play a role in SSD pathophysiology.