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Updated: Jan 7, 2026

High-frequency High-resolution Echocardiography: First Evidence on Non-invasive Repeated Measure of Myocardial Strain, Contractility, and Mitral Regurgitation in the Ischemia-reperfused Murine Heart
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Published on: July 9, 2010

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Global Longitudinal Strain and Biomarker Dynamics in Children With Acute Rheumatic Fever and Mitral Regurgitation: A

Serkan F Çelik1, Ugur Karagoz2

  • 1Pediatric Cardiology, Adnan Menderes University, Aydın, TUR.

Cureus
|December 25, 2025
PubMed

Insights

Global longitudinal strain (GLS) detects subclinical myocardial dysfunction in children with rheumatic heart disease. Impaired GLS in moderate mitral regurgitation highlights its value for monitoring.

Area of Science:

  • Pediatric Cardiology
  • Cardiovascular Imaging
  • Rheumatic Heart Disease

Background:

  • Acute rheumatic fever (ARF) is a major cause of acquired heart disease in children.
  • Subclinical myocardial dysfunction can occur even with preserved systolic function.
  • Global longitudinal strain (GLS) is a sensitive marker for early myocardial impairment.

Purpose of the Study:

  • To evaluate subclinical myocardial dysfunction in children with ARF-related carditis using GLS.
  • To assess the progression of myocardial dysfunction over one year.
  • To correlate GLS changes with mitral regurgitation (MR) severity.

Main Methods:

  • 30 children with ARF-related carditis and preserved systolic function were studied.
  • Patients were grouped by moderate (n=12) or mild (n=18) MR severity.
  • Echocardiography and speckle-tracking strain measures were assessed at baseline, 6, and 12 months.

Main Results:

  • GLS was significantly lower in ARF patients compared to controls at diagnosis and 6 months.
  • GLS improved in mild MR but remained impaired in moderate MR at 12 months.
  • GLS negatively correlated with valve regurgitation severity and NT-proBNP levels.

Conclusions:

  • GLS and NT-proBNP indicate subclinical myocardial dysfunction in pediatric ARF, particularly with moderate MR.
  • Longitudinal strain imaging aids early detection and long-term monitoring of ARF carditis.
Abstract

Keywords:
acute rheumatic feverechocardiographyglobal longitudinal strainmitral regurgitationnt-probnp

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