Tetrahydrocurcumin (THC) as a Melanogenesis Inhibitor in Melanoma Cell Lines

Melanin plays significant roles in biophysical, biochemical, light-filtering, and cosmetic functions of the skin. The melanin content in pigmented cells, such as melanoma cells, can be accurately measured. This study focused on evaluating the effects of tetrahydrocurcumin (THC), a hydrogenated derivative of curcuminoids, on melanogenesis in melanoma cells. We specifically investigated how THC influences melanin production and tyrosinase activity, a key enzyme in the melanogenesis pathway, in A375 melanoma cells. Our results provide experimental evidence supporting THC's potential as an inhibitor of melanin synthesis and tyrosinase activity. This suggests that THC could be an effective component in skin-whitening products. By demonstrating THC's ability to suppress melanin content and tyrosinase activity, our study highlights its potential for use as a dermatological agent in skincare formulations aimed at reducing pigmentation.