Clinical and systemic factors associated with pressure ulcer development: a retrospective evaluation of 339 patients

Fatih Oner Kaya1, Selçuk Şimşek2

  • 1Department of Internal Medicine, Maltepe University Hospital, Istanbul, Türkiye.

Frontiers in Medicine
|December 25, 2025
PubMed

Insights

Pressure ulcers affect over a third of palliative care patients, with stroke and confusion being major risks. Adhering to prevention protocols significantly reduces ulcer development.

Area of Science:

  • Palliative Care Medicine
  • Clinical Nursing
  • Gerontology

Background:

  • Pressure ulcers (PUs) are a significant complication in palliative care, often stemming from immobility and systemic illness.
  • Effective interventions require a deep understanding of the multifactorial risks associated with PU development.

Purpose of the Study:

  • To determine the prevalence of pressure ulcers in a palliative care setting.
  • To identify clinical and systemic risk factors contributing to PU development in this population.

Main Methods:

  • A retrospective single-center study analyzed medical records of 339 adult palliative care patients.
  • Data included demographics, comorbidities, Braden Scale, Care Dependency Scale (CDS) scores, and PU characteristics.
  • Multivariable logistic regression identified independent risk and protective factors for PU development.

Main Results:

  • The overall prevalence of pressure ulcers was 33.6%, with deep tissue injury being the most common type (26%).
  • Independent risk factors included stroke, gastrointestinal diseases, paraplegia, confusion, hypertension, coronary artery disease, arrhythmia, and heart failure. Longer hospital stays also increased risk.
  • Adherence to PU prevention protocols and complete care dependency were significant protective factors.

Conclusions:

  • Pressure ulcers are highly prevalent in palliative care patients, linked to numerous comorbid conditions.
  • Preventive strategies should target cardiovascular/neurological stability, cognitive function, and adherence to care protocols.
  • Integrating multidisciplinary management and individualized risk assessment is crucial for reducing PU burden and improving outcomes.
Abstract

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