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Blood Studies for Cardiovascular System I: Cardiac Biomarkers01:20

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Cardiac biomarkers are enzymes, proteins, and hormones released into the blood when cardiac cells are injured. They are powerful tools for triaging.
The essential diagnostic tools for detecting myocardial necrosis and monitoring individuals suspected of having acute coronary syndrome (ACS) include:
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Cardiac biomarkers are critical in diagnosing, prognosing, and managing cardiovascular diseases. Routine measurement of specific biomarkers such as B-type natriuretic peptide (BNP), C-reactive protein (CRP), and homocysteine (Hcy) is common practice in clinical settings to evaluate heart function and predict cardiovascular events.
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Dried Blood Spot Collection of Health Biomarkers to Maximize Participation in Population Studies
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Biomarkers.

Joseph R Winer1, Jacinda Taggett2, Margaret Scales3

  • 1Stanford University School of Medicine, Stanford, CA, USA.

Alzheimer'S & Dementia : the Journal of the Alzheimer'S Association
|December 25, 2025
PubMed
Summary
This summary is machine-generated.

Short sleep duration is linked to Alzheimer's disease biomarkers in older adults. Demographic factors associated with short sleep varied between study groups, highlighting the need to explore social and structural influences on sleep and brain health.

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Area of Science:

  • Neuroscience
  • Gerontology
  • Public Health

Background:

  • Short sleep duration is a known risk factor for Alzheimer's disease (AD) biomarkers in older adults.
  • Disparities in sleep health exist across the lifespan due to social and structural factors.
  • The impact of sleep health disparities on AD pathophysiology remains unclear.

Purpose of the Study:

  • To investigate the association between sleep duration, amyloid PET imaging, and demographic factors in two distinct cohorts of cognitively unimpaired older adults.
  • To compare these associations in the US POINTER cohort, which focused on under-represented groups (URG) and sedentary lifestyles, versus the A4 cohort.
  • To understand how demographic factors relate to short sleep duration and AD biomarkers.

Main Methods:

  • Compared self-reported sleep duration, amyloid PET imaging (using 18F-florbetaben and 18F-florbetapir), and demographics in US POINTER (N=426) and A4 (N=4485) cohorts.
  • Categorized participants reporting <7 hours of sleep as "short sleepers."
  • Analyzed amyloid positivity and centiloid values using cohort-specific processing pipelines.

Main Results:

  • US POINTER participants were more likely to be short sleepers (76% vs. 27% in A4) and identified more with URG.
  • Shorter sleep duration was linearly associated with higher amyloid centiloids in both cohorts.
  • In US POINTER, URG status was linked to short sleep; in A4, short sleep was associated with URG, lower education, and marginally higher centiloids.

Conclusions:

  • Short sleep duration is associated with amyloid PET biomarkers in cognitively unimpaired older adults.
  • Demographic factors linked to short sleep differ between cohorts, suggesting varied influences.
  • Further research is needed to elucidate the role of social and structural factors in sleep health and their downstream effects on AD pathophysiology.