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A Metadata Extraction Approach for Clinical Case Reports to Enable Advanced Understanding of Biomedical Concepts
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Clinical Manifestations.

Zaldy S Tan1, Nabeel Qureshi1,2, Andrew Hirsch1

  • 1Cedars-Sinai Medical Center, Los Angeles, CA, USA.

Alzheimer'S & Dementia : the Journal of the Alzheimer'S Association
|December 25, 2025
PubMed
Summary

Identifying modifiable risk factors for Alzheimer's disease and related dementias (ADRD) is crucial. A new program found high rates of sleep disorders, high cholesterol, and low physical activity in at-risk adults.

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Area of Science:

  • Neurology
  • Gerontology
  • Public Health

Background:

  • Alzheimer's disease and related dementias (ADRD) pose a significant public health challenge.
  • Modifiable medical and lifestyle factors are potential targets for reducing ADRD incidence.
  • The Cedars-Sinai Memory & Health Aging Program (MHAP) aims to promote brain health through personalized risk assessment and reduction strategies.

Purpose of the Study:

  • To describe the demographics and risk profiles of individuals participating in the MHAP program.
  • To identify common modifiable risk factors for ADRD in an at-risk, asymptomatic adult population.
  • To establish a baseline for future interventions aimed at mitigating ADRD risk.

Main Methods:

  • A cohort of Cedars-Sinai Medical Center patients aged 40+ without cognitive diagnoses were recruited via email.
  • Participants completed questionnaires on medical history and validated surveys for ADRD risk factors.
  • Descriptive statistics were used to analyze participant demographics and survey responses.

Main Results:

  • The study included 64 participants, with a mean age of 59.5 years; most were female (59.4%) and highly educated (95.3%).
  • High prevalence of ADRD risk factors included sleep disorders (75%), family history (69%), low physical activity (61%), and elevated LDL cholesterol (53%).
  • Montreal Cognitive Assessment (MoCA) scores averaged 26.1, with notable difficulties in delayed recall, language, and executive functions.

Conclusions:

  • Personalized risk profiling reveals a high burden of modifiable ADRD risk factors in at-risk adults.
  • Key identified risk factors include sleep disturbances, elevated LDL cholesterol, poor diet, and sedentary lifestyles.
  • Future research will focus on the efficacy of risk mitigation strategies on cognitive and brain aging.