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Updated: Jan 7, 2026

Dried Blood Spot Collection of Health Biomarkers to Maximize Participation in Population Studies

Dried Blood Spot Collection of Health Biomarkers to Maximize Participation in Population Studies

Published on: January 28, 2014

Biomarkers.

Lina Gomez¹, Jonny P Flint¹, Jessica Adsett¹

¹QIMR Berghofer Medical Research Institute, Brisbane, QLD, Australia.

Alzheimer'S & Dementia : the Journal of the Alzheimer'S Association

|December 25, 2025

Summary

This summary is machine-generated.

Online cognitive tests effectively measure brain health and Alzheimer's disease risk factors in adults. These accessible assessments show comparable results to in-person evaluations, aiding early detection.

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Area of Science:

Neuroscience
Cognitive Science
Gerontology

Background:

Online cognitive testing offers a flexible, cost-effective alternative to traditional in-person assessments.
The Creyos platform was utilized to evaluate cognitive functions in middle-aged and older adults within the Prospective Imaging Study of Aging (PISA).
PISA focuses on identifying early biomarkers for Alzheimer's disease in a large cohort.

Purpose of the Study:

To validate the Creyos online cognitive testing platform against comprehensive in-person assessments.
To assess the association between online cognitive measures and brain morphology (cortical sulcal width).
To investigate the link between cognitive performance and Alzheimer's disease risk factors and early biomarkers.

Main Methods:

Validation of the Creyos platform in 141 healthy PISA participants against in-person cognitive tests.
Multivariate analysis correlating cognitive test performance with cortical sulcal width from MRI scans.
Investigation of associations between cognitive measures and Alzheimer's disease Polygenic Risk Scores (PRS) in a large sample (N=2,000).

Main Results:

Online cognitive tests showed comparable associations with cortical sulcal width as in-person assessments.
A nominal association was found between Alzheimer's disease PRS and reduced performance in executive function, memory, and visuospatial domains.
Further analyses are ongoing to explore cognitive decline and its relation to Alzheimer's disease risk.

Conclusions:

Online cognitive assessments are comparable to in-person testing for evaluating brain morphology in at-risk populations.
Online testing is a valuable, cost-effective tool for large-scale studies and pre-screening for Alzheimer's disease risk.
This approach can promote equitable early detection and intervention for neurodegenerative diseases.