Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Blood Studies for Cardiovascular System I: Cardiac Biomarkers01:20

Blood Studies for Cardiovascular System I: Cardiac Biomarkers

749
Cardiac biomarkers are enzymes, proteins, and hormones released into the blood when cardiac cells are injured. They are powerful tools for triaging.
The essential diagnostic tools for detecting myocardial necrosis and monitoring individuals suspected of having acute coronary syndrome (ACS) include:
Troponins
Troponins, particularly cardiac troponins I and T, are the most precise and sensitive markers of myocardial injury. They are detectable within 4-6 hours of myocardial injury and remain...
749
Blood Studies for Cardiovascular System II: CRP, Hcy, and Cardiac Natriuretic Peptide Markers01:19

Blood Studies for Cardiovascular System II: CRP, Hcy, and Cardiac Natriuretic Peptide Markers

516
Cardiac biomarkers are critical in diagnosing, prognosing, and managing cardiovascular diseases. Routine measurement of specific biomarkers such as B-type natriuretic peptide (BNP), C-reactive protein (CRP), and homocysteine (Hcy) is common practice in clinical settings to evaluate heart function and predict cardiovascular events.
These markers indicate stress or strain on the heart muscle:
Natriuretic Peptides (BNP)
Cardiac myocytes produce these hormones in response to ventricular stretching...
516

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Cortical gray-white matter contrast alterations precede amyloid-β positivity and macrostructural changes in older adults without dementia.

Alzheimer's & dementia : the journal of the Alzheimer's Association·2026
Same author

Mediation Analysis Between Brain Age, Disease-Modifying Factors, and Disability and Cognitive Performance in Multiple Sclerosis.

Neurology·2026
Same author

Music processing in behavioural variant frontotemporal dementia and Alzheimer's disease: a functional MRI study.

Brain communications·2026
Same author

The collection of speech data for the assessment of cognition remotely: Balancing ethical and practical challenges.

Alzheimer's & dementia (Amsterdam, Netherlands)·2026
Same author

Amsterdam IMAging and Clinical GliOma Dataset; IMAGO.

Scientific data·2026
Same author

Decreased amyloid-related structure-function coupling in preclinical Alzheimer's disease.

Communications medicine·2026
Same journal

Multimorbidity burden and patterns associated with DeepBrainNet-derived brain-age gap in dementia-free older adults: A community-based study.

Alzheimer's & dementia : the journal of the Alzheimer's Association·2026
Same journal

Reply to "Shifting the emphasis of brain health literacy from individuals to systems to reduce inequalities".

Alzheimer's & dementia : the journal of the Alzheimer's Association·2026
Same journal

Shifting the emphasis of brain health literacy from individuals to systems to reduce inequalities.

Alzheimer's & dementia : the journal of the Alzheimer's Association·2026
Same journal

Correlates and predictors of self-efficacy among dementia caregivers: D-CARE findings.

Alzheimer's & dementia : the journal of the Alzheimer's Association·2026
Same journal

What should convince a clinician of disease modification in Alzheimer's disease clinical trials?

Alzheimer's & dementia : the journal of the Alzheimer's Association·2026
Same journal

Primary cilia-extracellular vesicle crosstalk in Alzheimer's disease: Emerging mechanisms and biomarker potential.

Alzheimer's & dementia : the journal of the Alzheimer's Association·2026
See all related articles

Related Experiment Video

Updated: Jan 7, 2026

Dried Blood Spot Collection of Health Biomarkers to Maximize Participation in Population Studies
07:20

Dried Blood Spot Collection of Health Biomarkers to Maximize Participation in Population Studies

Published on: January 28, 2014

37.1K

Biomarkers.

Prithvi Arunachalam1, Francesca Treves1,2, Leonard Pieperhoff1

  • 1Amsterdam University Medical Center (Amsterdam UMC), Amsterdam, North Holland, Netherlands.

Alzheimer'S & Dementia : the Journal of the Alzheimer'S Association
|December 25, 2025
PubMed
Summary
This summary is machine-generated.

Aging, sex, and amyloid burden impact brain connectivity differently. This study reveals how structural-functional coupling changes in older adults, offering insights into brain aging and early Alzheimer's disease (AD).

More Related Videos

Selecting Multiple Biomarker Subsets with Similarly Effective Binary Classification Performances
07:35

Selecting Multiple Biomarker Subsets with Similarly Effective Binary Classification Performances

Published on: October 11, 2018

7.9K
Ecotoxicological Methodologies to Evaluate Biomarkers at Different Scales in Neotropical Anurans
08:14

Ecotoxicological Methodologies to Evaluate Biomarkers at Different Scales in Neotropical Anurans

Published on: April 28, 2023

702

Related Experiment Videos

Last Updated: Jan 7, 2026

Dried Blood Spot Collection of Health Biomarkers to Maximize Participation in Population Studies
07:20

Dried Blood Spot Collection of Health Biomarkers to Maximize Participation in Population Studies

Published on: January 28, 2014

37.1K
Selecting Multiple Biomarker Subsets with Similarly Effective Binary Classification Performances
07:35

Selecting Multiple Biomarker Subsets with Similarly Effective Binary Classification Performances

Published on: October 11, 2018

7.9K
Ecotoxicological Methodologies to Evaluate Biomarkers at Different Scales in Neotropical Anurans
08:14

Ecotoxicological Methodologies to Evaluate Biomarkers at Different Scales in Neotropical Anurans

Published on: April 28, 2023

702

Area of Science:

  • Neuroscience
  • Brain Imaging
  • Connectomics

Background:

  • Brain function relies on structural pathways for neural communication.
  • The relationship between brain structure and function (coupling) varies regionally and is altered in aging and Alzheimer's disease (AD).
  • This study examines how age, sex, and amyloid pathology affect structural-functional coupling in non-demented older adults.

Purpose of the Study:

  • To investigate the influence of age, sex, and amyloid burden on structural-functional coupling in the aging brain.
  • To determine regional variations in structural-functional coupling.
  • To understand how these factors relate to early pathological changes relevant to Alzheimer's disease (AD).

Main Methods:

  • Utilized diffusion-weighted imaging (DWI), functional magnetic resonance imaging (fMRI), and amyloid positron emission tomography (PET) from 439 participants.
  • Computed the Structural-Decoupling Index (SDI) using a graph signal processing framework to quantify the ratio of decoupled to coupled brain activity.
  • Employed linear models to assess the impact of age, sex, and amyloid burden (Centiloid scale) on global, network, and regional SDI.

Main Results:

  • Age showed no global effect on SDI but was linked to increased decoupling in the somatomotor network.
  • Males exhibited globally lower SDI, particularly in fronto-temporal regions.
  • Higher amyloid burden correlated with increased global and network-level SDI, especially in the default mode and frontoparietal networks, and regionally in the inferior temporal cortex.

Conclusions:

  • Age, sex, and amyloid burden independently affect structural-functional brain coupling across different scales.
  • These findings underscore the utility of multimodal neuroimaging in detecting subtle brain changes.
  • The study highlights distinct pathophysiological processes associated with aging and early Alzheimer's disease (AD).