Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Blood Studies for Cardiovascular System I: Cardiac Biomarkers01:20

Blood Studies for Cardiovascular System I: Cardiac Biomarkers

746
Cardiac biomarkers are enzymes, proteins, and hormones released into the blood when cardiac cells are injured. They are powerful tools for triaging.
The essential diagnostic tools for detecting myocardial necrosis and monitoring individuals suspected of having acute coronary syndrome (ACS) include:
Troponins
Troponins, particularly cardiac troponins I and T, are the most precise and sensitive markers of myocardial injury. They are detectable within 4-6 hours of myocardial injury and remain...
746
Blood Studies for Cardiovascular System II: CRP, Hcy, and Cardiac Natriuretic Peptide Markers01:19

Blood Studies for Cardiovascular System II: CRP, Hcy, and Cardiac Natriuretic Peptide Markers

511
Cardiac biomarkers are critical in diagnosing, prognosing, and managing cardiovascular diseases. Routine measurement of specific biomarkers such as B-type natriuretic peptide (BNP), C-reactive protein (CRP), and homocysteine (Hcy) is common practice in clinical settings to evaluate heart function and predict cardiovascular events.
These markers indicate stress or strain on the heart muscle:
Natriuretic Peptides (BNP)
Cardiac myocytes produce these hormones in response to ventricular stretching...
511

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Sex-specific mitochondrial dysregulation and metformin response in Wilson disease.

Scientific reports·2026
Same author

The blood metabolome of brain health in midlife and influences of genes, microbiome and exposome.

Nature aging·2026
Same author

Interconnected influences of diet, gut microbiome, and metabolome on cognition across three metabolomics platforms.

Research square·2026
Same author

Partial body mass regain attenuates lipid utilization and alters the hepatic lipidome linked to HDL dysfunction during metabolic syndrome in male rats.

Physiological reports·2026
Same author

Inverse Association between the ω-3 Index and Neutrophil-Lymphocyte Ratio: Pooled Results from Four Supplementation Trials.

The Journal of nutrition·2026
Same author

Exposome contribution to the brain metabolome: importance of body brain connection.

medRxiv : the preprint server for health sciences·2026
Same journal

Multimorbidity burden and patterns associated with DeepBrainNet-derived brain-age gap in dementia-free older adults: A community-based study.

Alzheimer's & dementia : the journal of the Alzheimer's Association·2026
Same journal

Reply to "Shifting the emphasis of brain health literacy from individuals to systems to reduce inequalities".

Alzheimer's & dementia : the journal of the Alzheimer's Association·2026
Same journal

Shifting the emphasis of brain health literacy from individuals to systems to reduce inequalities.

Alzheimer's & dementia : the journal of the Alzheimer's Association·2026
Same journal

Correlates and predictors of self-efficacy among dementia caregivers: D-CARE findings.

Alzheimer's & dementia : the journal of the Alzheimer's Association·2026
Same journal

What should convince a clinician of disease modification in Alzheimer's disease clinical trials?

Alzheimer's & dementia : the journal of the Alzheimer's Association·2026
Same journal

Primary cilia-extracellular vesicle crosstalk in Alzheimer's disease: Emerging mechanisms and biomarker potential.

Alzheimer's & dementia : the journal of the Alzheimer's Association·2026
See all related articles

Related Experiment Video

Updated: Jan 7, 2026

Dried Blood Spot Collection of Health Biomarkers to Maximize Participation in Population Studies
07:20

Dried Blood Spot Collection of Health Biomarkers to Maximize Participation in Population Studies

Published on: January 28, 2014

37.1K

Biomarkers.

Sitong Zhou1, Kamil Borkowski2, Angela M Zivkovic2

  • 1University of California Davis Medical Center, Sacramento, CA, USA.

Alzheimer'S & Dementia : the Journal of the Alzheimer'S Association
|December 25, 2025
PubMed
Summary
This summary is machine-generated.

Alzheimer's disease (AD) involves inflammation, with altered oxylipins (oxidized lipids) in lipoproteins like LDL and VLDL. These changes are sex- and ApoE-specific, offering potential AD biomarkers.

More Related Videos

Selecting Multiple Biomarker Subsets with Similarly Effective Binary Classification Performances
07:35

Selecting Multiple Biomarker Subsets with Similarly Effective Binary Classification Performances

Published on: October 11, 2018

7.9K
Ecotoxicological Methodologies to Evaluate Biomarkers at Different Scales in Neotropical Anurans
08:14

Ecotoxicological Methodologies to Evaluate Biomarkers at Different Scales in Neotropical Anurans

Published on: April 28, 2023

699

Related Experiment Videos

Last Updated: Jan 7, 2026

Dried Blood Spot Collection of Health Biomarkers to Maximize Participation in Population Studies
07:20

Dried Blood Spot Collection of Health Biomarkers to Maximize Participation in Population Studies

Published on: January 28, 2014

37.1K
Selecting Multiple Biomarker Subsets with Similarly Effective Binary Classification Performances
07:35

Selecting Multiple Biomarker Subsets with Similarly Effective Binary Classification Performances

Published on: October 11, 2018

7.9K
Ecotoxicological Methodologies to Evaluate Biomarkers at Different Scales in Neotropical Anurans
08:14

Ecotoxicological Methodologies to Evaluate Biomarkers at Different Scales in Neotropical Anurans

Published on: April 28, 2023

699

Area of Science:

  • Neuroscience
  • Biochemistry
  • Lipidomics

Background:

  • Inflammation is central to Alzheimer's Disease (AD) pathology.
  • Oxylipins, oxidized lipid derivatives, modulate inflammatory pathways.
  • Soluble epoxide hydrolase (sEH) dysregulation is noted in AD, impacting oxylipin metabolism.
  • Over 90% of oxylipins circulate esterified within lipoproteins, but their role in AD is unclear.

Purpose of the Study:

  • Investigate lipoprotein-associated oxylipin alterations in mild cognitive impairment (MCI) and AD.
  • Determine the influence of sex and ApoE genotype on these lipid mediators.
  • Explore the link between lipoprotein-mediated oxylipin metabolism and cognitive decline.

Main Methods:

  • Isolated plasma low-density lipoprotein (LDL) and very low-density lipoprotein (VLDL) from controls, MCI, and AD participants.
  • Quantified esterified oxylipins using liquid chromatography-tandem mass spectrometry (LC-MS/MS).
  • Analyzed metabolite associations with cognitive status, adjusting for covariates and exploring sex-specific differences.

Main Results:

  • Lipoprotein-associated oxylipins differ significantly in MCI and AD patients compared to controls.
  • Pro-inflammatory diols decreased in female LDL, while pro-resolving epoxides increased in female LDL and male LDL/VLDL with cognitive decline.
  • Oxylipins from lipoxygenase/auto-oxidative pathways (HODEs, HOTEs, HEPEs) increased with cognitive decline.
  • ApoE genotype modulated these changes, with ApoE3/4 carriers showing elevated epoxides, suggesting reduced anti-inflammatory tone.

Conclusions:

  • Significant alterations in lipoprotein-associated oxylipins occur across the AD spectrum (MCI to AD).
  • Lipoprotein-mediated oxylipin dysregulation is sex- and ApoE-specific, involving sEH and lipoxygenase pathways.
  • These findings highlight inflammation's role in AD and support lipoproteins influencing neuroinflammation, potentially aiding AD biomarker development.