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Related Experiment Video

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A Metadata Extraction Approach for Clinical Case Reports to Enable Advanced Understanding of Biomedical Concepts
07:50

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Clinical Manifestations.

Ángela Acosta-Amaya1,2, Salvador Sánchez-Badajos3, Diego Solano-Mendoza4

  • 1Universidad Nacional Autónoma de México, México, EM, Mexico.

Alzheimer'S & Dementia : the Journal of the Alzheimer'S Association
|December 25, 2025
PubMed
Summary
This summary is machine-generated.

Subjective cognitive decline (SCD) and mild cognitive impairment (MCI) are associated with the APOEε4 allele in older Mexican adults. Carrying the APOEε4 allele increases the risk for both SCD and MCI, highlighting SCD as an early risk indicator for Alzheimer's disease continuum.

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Area of Science:

  • Neuroscience
  • Genetics
  • Gerontology

Background:

  • Subjective cognitive decline (SCD) signifies self-reported cognitive impairment without objective deficits, posing a risk for mild cognitive impairment (MCI) and dementia.
  • SCD and MCI represent early stages (2 and 3) in the Alzheimer's disease (AD) continuum.
  • The APOEε4 allele is a known risk factor for AD, and its interaction with cognitive decline warrants investigation.

Purpose of the Study:

  • To investigate the relationship between subjective cognitive decline (SCD), mild cognitive impairment (MCI), and APOEε4 allele status in Mexican-mestizo older adults.
  • To determine if APOEε4 carrier status influences the risk of SCD or MCI in this population.

Main Methods:

  • A study involving 84 Mexican-mestizo older adults, categorized into normal cognition (NC), SCD, and MCI groups (n=28 each).
  • Cognitive function assessed using the Montreal Cognitive Assessment (MoCA) and cognitive complaints via the Cognitive Complaint Questionnaire (CCQ).
  • APOE genotyping performed to determine allele status; statistical analyses conducted using SPSS.

Main Results:

  • Significant cognitive performance differences were found between NC and MCI groups.
  • The APOEε4 allele frequency was significantly higher in both SCD and MCI groups compared to the NC group.
  • Carrying the APOEε4 allele increased the risk for both SCD (OR=5.17) and MCI (OR=6.60) compared to normal cognition.

Conclusions:

  • An association exists between SCD, MCI, and the APOEε4 allele in Mexican-mestizo older adults.
  • APOEε4 carrier status presents a comparable risk for both SCD and MCI, underscoring SCD's role as a predictor in the AD continuum.
  • Further research into SCD is crucial for early dementia detection and prevention strategies.