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Related Concept Videos

Blood Studies for Cardiovascular System I: Cardiac Biomarkers01:20

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Cardiac biomarkers are enzymes, proteins, and hormones released into the blood when cardiac cells are injured. They are powerful tools for triaging.
The essential diagnostic tools for detecting myocardial necrosis and monitoring individuals suspected of having acute coronary syndrome (ACS) include:
Troponins
Troponins, particularly cardiac troponins I and T, are the most precise and sensitive markers of myocardial injury. They are detectable within 4-6 hours of myocardial injury and remain...
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Blood Studies for Cardiovascular System II: CRP, Hcy, and Cardiac Natriuretic Peptide Markers01:19

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Cardiac biomarkers are critical in diagnosing, prognosing, and managing cardiovascular diseases. Routine measurement of specific biomarkers such as B-type natriuretic peptide (BNP), C-reactive protein (CRP), and homocysteine (Hcy) is common practice in clinical settings to evaluate heart function and predict cardiovascular events.
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Cardiac myocytes produce these hormones in response to ventricular stretching...
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Dried Blood Spot Collection of Health Biomarkers to Maximize Participation in Population Studies
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Biomarkers.

Talia L Robinson1, Theresa M Harrison2, Kathryn V Papp3

  • 1Massachusetts General Hospital, Boston, MA, USA.

Alzheimer'S & Dementia : the Journal of the Alzheimer'S Association
|December 25, 2025
PubMed
Summary
This summary is machine-generated.

Alzheimer's disease (AD) biomarkers like amyloid-beta (Aβ) and tau show similar relationships with cognitive decline in Black and White individuals. However, biomarker levels varied between groups, highlighting the need for diverse research.

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Area of Science:

  • Neuroscience
  • Gerontology
  • Public Health

Background:

  • Alzheimer's disease (AD) research lacks diverse populations, limiting generalizability of findings.
  • Understanding AD biomarker associations in Non-Hispanic Black (NHB) and Non-Hispanic White (NHW) individuals is crucial.

Purpose of the Study:

  • To evaluate associations between key AD biomarkers (amyloid-beta and tau) and cognitive performance in cognitively unimpaired NHB and NHW participants.
  • To assess if AD biomarker relationships differ across ethnoracial groups within two distinct cohorts.

Main Methods:

  • Analysis of amyloid-beta (Aβ) and entorhinal cortex (EC) tau PET imaging in NHB and NHW participants from ADNI and POINTER Imaging cohorts.
  • Examination of relationships between Aβ and EC tau, and EC tau and Preclinical Alzheimer's Cognitive Composite (PACC) scores.
  • Regression and interaction models adjusted for age, gender, and education to compare ethnoracial group associations.

Main Results:

  • NHB participants had lower Aβ and EC tau burden than NHW participants in the POINTER cohort, but not in ADNI.
  • Associations between Aβ and EC tau varied across cohorts and ethnoracial groups.
  • EC tau was consistently associated with worse PACC performance in both NHB and NHW individuals, with no significant differences between groups.

Conclusions:

  • While AD biomarker levels and Aβ-tau associations may differ between NHB and NHW individuals, AD biomarkers appear similarly related to cognitive outcomes across these groups.
  • Further research with diverse samples and harmonized data is needed to confirm the generalizability of AD biomarker relationships.