Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Infection01:20

Infection

11.6K
When a pathogen enters the body and reproduces, it can cause an infection, damage body cells, and cause illness symptoms that eventually lead to disease. Therefore, its prevention requires breaking the chain of infection.
The chain begins with pathogens: bacteria, viruses, fungi, prions, or parasites such as protozoa helminths. These can be present on the skin as transient or resident flora, or they can be acquired from the environment. Identifying and treating the type of infection and...
11.6K
Urinary Tract Infection II: Pathophysiology01:25

Urinary Tract Infection II: Pathophysiology

521
The pathophysiology of urinary tract infections (UTIs) encompasses several progressive stages, beginning with bacterial colonization and culminating in potential systemic complications if untreated. UTIs are primarily initiated by bacteria, such as Escherichia coli, which often originate from the gastrointestinal tract and migrate to the urinary system through the periurethral area. This migration can occur via several routes, including improper hygiene practices, sexual activity, or...
521
Cystic Fibrosis: Pathogenesis01:23

Cystic Fibrosis: Pathogenesis

674
Cystic fibrosis (CF), an autosomal recessive disorder, significantly affects the function of exocrine glands. This genetically inherited disease is characterized by the production of thick and sticky mucus, which can severely affect various organs and systems in the body.
CF is primarily caused by a genetic mutation in a chromosome 7 gene coding for the cystic fibrosis transmembrane conductance regulator (CFTR) protein. The most common gene mutation leading to CF is the ΔF508 mutation,...
674
Pneumonia II: Pathophysiology01:29

Pneumonia II: Pathophysiology

2.5K
The pathophysiology of pneumonia involves the following steps:
2.5K
Stages of Infection01:26

Stages of Infection

64.7K
Stages of infection describe what happens to a susceptible host once a pathogen invades the human body. The stages of infection are incubation, prodromal, illness, stage of decline, and convalescence. The incubation stage is the period from exposure to a pathogen until symptoms start. The infected person is unaware of impending illness as the pathogens grow and multiply within the body. The duration may vary depending on the type of infection. The incubation period of measles averages ten to...
64.7K
Defense Against Bacterial Pathogens01:31

Defense Against Bacterial Pathogens

2.6K
The human immune system is a complex network of cells, tissues, and organs that work together to defend the body against bacterial infections. It consists of various immune cells, each playing a specific role in the defense mechanism.
Phagocytes
Phagocytes are the frontline soldiers of the immune system. They include neutrophils and macrophages. Neutrophils are the most abundant type of white blood cell and are quickly mobilized to the site of infection. Macrophages are larger cells that patrol...
2.6K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Self-assembled polypeptide micelles for fungal keratitis treatment.

Chemical communications (Cambridge, England)·2026
Same author

Extracellular vesicles derived from ovarian cancer cells promote tumor progression through m2 macrophage polarization and enhanced angiogenesis.

BMC cancer·2026
Same author

Regional heterogeneity in fibrotic scar formation and early functional recovery in cervical, thoracic, and lumbar spinal cord injuries.

Neural regeneration research·2026
Same author

Corrigendum to 'An injectable thermoresponsive-hydrogel for lamellar keratoplasty: In-situ releases celastrol and hampers corneal scars [Journal of Controlled Release 369 (2024) 604-616].

Journal of controlled release : official journal of the Controlled Release Society·2026
Same author

Ganglioside sialylation modulates tau internalization and pathology spread.

Molecular psychiatry·2025
Same author

Publisher Correction: amorphous layered double hydroxide-based nano-enzyme eye drops against dry eye disease by inhibiting mitochondrial damage and pyroptosis.

Journal of nanobiotechnology·2025

Related Experiment Video

Updated: Jan 7, 2026

Mouse Footpad Inoculation Model to Study Viral-Induced Neuroinflammatory Responses
09:07

Mouse Footpad Inoculation Model to Study Viral-Induced Neuroinflammatory Responses

Published on: June 14, 2020

11.5K

Basic Science and Pathogenesis.

Fei Liu1, Ruozhen Wu1,2, Dandan Chu1,3

  • 1New York State Institute for Basic Research in Developmental Disabilities, Staten Island, NY, USA.

Alzheimer'S & Dementia : the Journal of the Alzheimer'S Association
|December 25, 2025
PubMed
Summary
This summary is machine-generated.

Removing tau's N- and C-termini creates tau aggregates that mimic Alzheimer's disease pathology. These truncated tau aggregates promote further tau aggregation and hyperphosphorylation in cells and mouse brains.

More Related Videos

A Precise Pathogen Delivery and Recovery System for Murine Models of Secondary Bacterial Pneumonia
13:45

A Precise Pathogen Delivery and Recovery System for Murine Models of Secondary Bacterial Pneumonia

Published on: September 21, 2019

6.0K
Using a Bacterial Pathogen to Probe for Cellular and Organismic-level Host Responses
08:38

Using a Bacterial Pathogen to Probe for Cellular and Organismic-level Host Responses

Published on: February 22, 2019

6.3K

Related Experiment Videos

Last Updated: Jan 7, 2026

Mouse Footpad Inoculation Model to Study Viral-Induced Neuroinflammatory Responses
09:07

Mouse Footpad Inoculation Model to Study Viral-Induced Neuroinflammatory Responses

Published on: June 14, 2020

11.5K
A Precise Pathogen Delivery and Recovery System for Murine Models of Secondary Bacterial Pneumonia
13:45

A Precise Pathogen Delivery and Recovery System for Murine Models of Secondary Bacterial Pneumonia

Published on: September 21, 2019

6.0K
Using a Bacterial Pathogen to Probe for Cellular and Organismic-level Host Responses
08:38

Using a Bacterial Pathogen to Probe for Cellular and Organismic-level Host Responses

Published on: February 22, 2019

6.3K

Area of Science:

  • Neuroscience
  • Biochemistry
  • Pathology

Background:

  • Neurofibrillary tangles (NFTs) composed of hyperphosphorylated tau are key in Alzheimer's disease (AD).
  • Tau pathology spreads via prion-like mechanisms, originating in specific brain regions and progressing over time.
  • In AD, tau loses its N- and C-termini, potentially driving self-aggregation and disease progression.

Purpose of the Study:

  • To investigate the role of tau termini deletion in tau aggregation and proteopathic properties.
  • To determine if truncated tau can induce tau pathology in vitro and in vivo.

Main Methods:

  • Generated a truncated tau protein (tau151-391) lacking N- and C-termini.
  • Induced tau aggregation using ultracentrifugation and overexpressed in HEK-293T cells.
  • Assessed phosphorylation and proteopathic properties in vitro and in vivo.

Main Results:

  • Truncated tau (tau151-391) formed aggregates in cells and mouse brains, unlike full-length tau.
  • Aggregated tau151-391 was hyperphosphorylated and partially resistant to proteinase K digestion.
  • Tau151-391 aggregates induced further tau aggregation and hyperphosphorylation in cells and mouse brains.

Conclusions:

  • Deletion of tau's N- and C-termini promotes aggregation and confers proteopathic characteristics.
  • Tau151-391 aggregates are potent inducers of tau aggregation and site-specific hyperphosphorylation.