Related Experiment Video
Updated: Jan 7, 2026
05:10
Drug Repurposing Hypothesis Generation Using the "RE:fine Drugs" System
Published on: December 11, 2016
10.1K
Drug Development
Vincent O Olughor1, Kemi O Charles-Okhe1, Amany K Ladagu2
1Faculty of Pharmacy, University of Ibadan, Ibadan, Nigeria.
Alzheimer'S & Dementia : the Journal of the Alzheimer'S Association
|December 25, 2025
Summary
Preventing Alzheimer's disease (AD) involves addressing micronutrient deficiencies and neurotoxin exposure. A nutraceutical therapy could restore nutrient balance and protect against neurodegeneration, potentially preventing FAD.
Area of Science:
- Neuroscience
- Nutritional Science
- Biochemistry
Background:
- Alzheimer's disease (AD) onset is linked to elevated plasma 24-hydroxycholesterol.
- Risk factors for AD progression include micronutrient deficiencies, low antioxidant levels, neurotoxin exposure, and disrupted autophagy.
- These factors can lead to Wallerian-type degeneration of cholinergic neurons, ultimately causing AD.
Purpose of the Study:
- To review risk factors contributing to Alzheimer's disease (AD).
- To explore intervention therapies for reverting these risk factors.
- To establish prevention strategies for AD, focusing on acetylcholine depletion and memory loss.
Main Methods:
- Literature review on risk factors for AD.
- Analysis of intervention therapies for risk factor management.
- Focus on preventing neurodegeneration and neurotransmitter depletion.
Main Results:
- Micronutrient deficiencies (e.g., calcium, iron, vitamin D) can increase neurotoxic lead absorption.
- Low antioxidant levels allow lipophilic neurotoxins to compromise the blood-brain barrier (BBB), leading to neurodegeneration.
- Autophagy dysregulation is implicated in AD and other neurodegenerative diseases.
Conclusions:
- A nutraceutical therapy is proposed for AD prevention.
- This therapy will provide essential nutrients (macro, micro, phyto) to maintain optimal plasma pH (7.35-7.45).
- The formulation aims to prevent the physiological disruptions leading to AD.
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