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Related Concept Videos

Blood Studies for Cardiovascular System I: Cardiac Biomarkers01:20

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Cardiac biomarkers are enzymes, proteins, and hormones released into the blood when cardiac cells are injured. They are powerful tools for triaging.
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Cardiac biomarkers are critical in diagnosing, prognosing, and managing cardiovascular diseases. Routine measurement of specific biomarkers such as B-type natriuretic peptide (BNP), C-reactive protein (CRP), and homocysteine (Hcy) is common practice in clinical settings to evaluate heart function and predict cardiovascular events.
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Updated: Jan 7, 2026

Dried Blood Spot Collection of Health Biomarkers to Maximize Participation in Population Studies
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Biomarkers.

Johannes C Michaelian1,2, Azadeh Feizpour3, James C Vickers4

  • 1Healthy Brain Ageing Program, Brain and Mind Centre, School of Psychology, Faculty of Science, University of Sydney, Camperdown, NSW, Australia.

Alzheimer'S & Dementia : the Journal of the Alzheimer'S Association
|December 25, 2025
PubMed
Summary
This summary is machine-generated.

A new Alzheimer's disease (AD) blood test shows promise in improving diagnostic accuracy. The test, measuring plasma pTau181 levels, increased clinician confidence in diagnosing AD, especially in early stages.

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Area of Science:

  • Neurology
  • Biomarker Discovery
  • Diagnostic Medicine

Background:

  • Recent advancements enable blood tests for Alzheimer's disease (AD) biomarkers.
  • Non-invasive, cost-effective AD blood tests can improve early diagnosis and treatment initiation.

Purpose of the Study:

  • To evaluate the impact of disclosing AD probability via plasma pTau181 levels on clinician diagnostic confidence and management.
  • To assess the utility of a novel blood test in a clinical setting.

Main Methods:

  • A before-and-after study was conducted in three Australian Memory and Cognition Clinics.
  • Plasma pTau181 levels were measured using the Quanterix Simoa™ platform.
  • Results were reported as probably negative, indeterminate, or probably positive to clinicians.

Main Results:

  • 113 participants with dementia, mild cognitive impairment, or subjective cognitive decline were enrolled.
  • Blood test results changed diagnosis in 12.4% of cases, increasing clinician confidence from 63.1% to 78.6%.
  • Two-thirds of clinicians supported the clinical use of such blood tests with further refinement.

Conclusions:

  • Plasma pTau181 blood tests have the potential to enhance diagnostic accuracy in clinical practice.
  • The study demonstrates improved diagnostic confidence in patients with initially low-to-moderate confidence levels.