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Emily A Largent1, Josh D Grill2, Jason Karlawish3

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Summary
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The study partner requirement in Alzheimer's disease prevention trials may hinder recruitment. However, Black older adults' underrepresentation is not due to lower participation intentions, suggesting other barriers exist.

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Area of Science:

  • Neuroscience
  • Clinical Trials
  • Public Health

Background:

  • Recruiting representative samples for Alzheimer's disease secondary prevention trials is crucial for effective treatment.
  • Past research indicates the "study partner" requirement may disproportionately affect enrollment of underrepresented racial and ethnic groups.

Purpose of the Study:

  • To assess the impact of the study partner requirement on enrollment intentions in secondary prevention trials.
  • To investigate potential racial and ethnic disparities in participation and study partner recruitment intentions.

Main Methods:

  • A national survey of U.S. adults aged 65+ was conducted, oversampling Black individuals.
  • Participants indicated their intention to enroll in a hypothetical trial and to ask someone to be a study partner.
  • Descriptive statistics and difference calculations were used to analyze enrollment and study partner intentions.

Main Results:

  • Intention to enroll in the HEALTHY MIND Study was generally low (24% of respondents).
  • Among those intending to enroll, the intention to ask a study partner was moderate (mean score 3.45).
  • No significant differences were found between Black and White respondents in their intention to enroll or ask a study partner.

Conclusions:

  • The study partner requirement appears to be a barrier to recruitment in secondary prevention trials.
  • Underrepresentation of Black older adults is not explained by lower participation or study partner intentions.
  • Other factors, such as restrictive inclusion criteria or structural barriers, likely contribute to the lack of representation.