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Related Concept Videos

Blood Studies for Cardiovascular System I: Cardiac Biomarkers01:20

Blood Studies for Cardiovascular System I: Cardiac Biomarkers

746
Cardiac biomarkers are enzymes, proteins, and hormones released into the blood when cardiac cells are injured. They are powerful tools for triaging.
The essential diagnostic tools for detecting myocardial necrosis and monitoring individuals suspected of having acute coronary syndrome (ACS) include:
Troponins
Troponins, particularly cardiac troponins I and T, are the most precise and sensitive markers of myocardial injury. They are detectable within 4-6 hours of myocardial injury and remain...
746
Blood Studies for Cardiovascular System II: CRP, Hcy, and Cardiac Natriuretic Peptide Markers01:19

Blood Studies for Cardiovascular System II: CRP, Hcy, and Cardiac Natriuretic Peptide Markers

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Cardiac biomarkers are critical in diagnosing, prognosing, and managing cardiovascular diseases. Routine measurement of specific biomarkers such as B-type natriuretic peptide (BNP), C-reactive protein (CRP), and homocysteine (Hcy) is common practice in clinical settings to evaluate heart function and predict cardiovascular events.
These markers indicate stress or strain on the heart muscle:
Natriuretic Peptides (BNP)
Cardiac myocytes produce these hormones in response to ventricular stretching...
511

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Updated: Jan 7, 2026

Dried Blood Spot Collection of Health Biomarkers to Maximize Participation in Population Studies
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Biomarkers.

Kristofer Harris1, Madison Shyer2, Paul E Schulz1

  • 1John P. and Kathrine G. McGovern Medical School at UTHealth, Houston, TX, USA.

Alzheimer'S & Dementia : the Journal of the Alzheimer'S Association
|December 25, 2025
PubMed
Summary
This summary is machine-generated.

Untreated hyperlipidemia and diabetes are risk factors for naturally occurring amyloid-related imaging abnormalities-hemosiderin (ARIA-H) in Alzheimer's disease patients. Managing cardiovascular health may reduce ARIA-H incidence.

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Area of Science:

  • Neurology
  • Gerontology
  • Radiology

Background:

  • Amyloid-related imaging abnormalities-hemosiderin (ARIA-H) are cerebrovascular changes seen in Alzheimer's disease (AD).
  • ARIA-H can occur naturally in AD patients, independent of anti-amyloid immunotherapies.
  • Identifying risk factors for naturally occurring ARIA-H is crucial for patient management.

Purpose of the Study:

  • To explore associated risk factors for naturally occurring ARIA-H in Alzheimer's disease patients.
  • To differentiate naturally occurring ARIA-H from treatment-related ARIA-H.

Main Methods:

  • Analysis of placebo arm data from the EXPEDITION 1 randomized control trial.
  • Inclusion criteria: baseline and post-baseline MRI data with microhemorrhage information.
  • Statistical analysis of demographics, comorbidities, medications, cognitive scores, CSF, MRI, and PET data.

Main Results:

  • 21 out of 460 patients (4.2%) developed incident ARIA-H.
  • Significant risk factors identified: untreated hyperlipidemia (p=0.01), diabetes diagnosis (p=0.04), ARIA-H at baseline (p=0.04), and higher baseline CSF t-Tau (p=0.03).
  • APOE 4 status, age, anticoagulant, and antiplatelet use were not significantly associated with incident ARIA-H.

Conclusions:

  • Untreated hyperlipidemia and diabetes may be modifiable risk factors for naturally occurring ARIA-H in AD.
  • Prioritizing interventions for cardiovascular diseases like hyperlipidemia could reduce ARIA-H likelihood.
  • Further validation using EXPEDITION 2 and 3 data is recommended to guide clinical decisions.