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Related Concept Videos

Blood Studies for Cardiovascular System I: Cardiac Biomarkers01:20

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Cardiac biomarkers are enzymes, proteins, and hormones released into the blood when cardiac cells are injured. They are powerful tools for triaging.
The essential diagnostic tools for detecting myocardial necrosis and monitoring individuals suspected of having acute coronary syndrome (ACS) include:
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Cardiac biomarkers are critical in diagnosing, prognosing, and managing cardiovascular diseases. Routine measurement of specific biomarkers such as B-type natriuretic peptide (BNP), C-reactive protein (CRP), and homocysteine (Hcy) is common practice in clinical settings to evaluate heart function and predict cardiovascular events.
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Dried Blood Spot Collection of Health Biomarkers to Maximize Participation in Population Studies
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Biomarkers.

Zhen Qiao1, Lin Ai2

  • 1Beijing Tiantan Hospital, Beijing, Beijing, China.

Alzheimer'S & Dementia : the Journal of the Alzheimer'S Association
|December 25, 2025
PubMed
Summary
This summary is machine-generated.

Amyloid-beta (Aβ) deposition patterns were analyzed in patients with cognitive impairment and hallucinations. Findings suggest preferential Aβ deposition in the left occipital cortex for hallucinating patients.

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Area of Science:

  • Neuroscience
  • Medical Imaging
  • Neuropathology

Background:

  • Investigating the neuropathological underpinnings of hallucinations in cognitive impairment is crucial for understanding disease progression.
  • Amyloid-beta (Aβ) deposition is a hallmark of several neurodegenerative diseases, but its specific distribution in patients with cognitive impairment and hallucinations requires further elucidation.

Purpose of the Study:

  • To characterize the patterns of Aβ deposition in patients experiencing cognitive impairment with hallucinations (CI-H) compared to those without hallucinations (CI-N).
  • To identify specific brain regions with altered Aβ accumulation in CI-H patients.

Main Methods:

  • Retrospective analysis of AV45 Positron Emission Tomography (PET) imaging data from 9 CI-H patients and 9 CI-N patients.
  • Utilized the cortexID suite for data analysis, with the whole cerebellum as the reference region to calculate Standardized Uptake Value Ratios (SUVR) for cortical regions.

Main Results:

  • While overall Aβ deposition (SUVR) was similar between groups, 66.7% of CI-H patients showed highest uptake in the occipital cortex, versus 22.2% in CI-N patients.
  • The occipital lobe showed higher SUVR in the CI-H group (Left: 1.39±0.24, Right: 1.33±0.22) compared to the CI-N group (Left: 1.34±0.24, Right: 1.29±0.19), though not statistically significant.
  • Aβ deposition was more frequently localized to the left occipital cortex in the CI-H group.

Conclusions:

  • Amyloid-beta preferentially deposits in the left occipital cortex of patients with cognitive impairment who experience hallucinations.
  • These findings may contribute to understanding the neurobiological basis of hallucinations in certain cognitive impairment conditions.