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Clinical Manifestations.

Catherine Bikeri Onyancha1, Benard O Aliwa2, Jasmit Shah3

  • 1Brain and Mind Institute, Aga Khan University, Nairobi, Kenya.

Alzheimer'S & Dementia : the Journal of the Alzheimer'S Association
|December 25, 2025
PubMed
Summary
This summary is machine-generated.

Psychological distress and subjective cognitive concerns are linked to clinical health markers in African adults. Demographic factors like age and gender may influence these dementia risk associations.

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Area of Science:

  • Neuroscience
  • Public Health
  • Gerontology

Background:

  • Psychological distress is a known dementia risk factor, impacting aging processes.
  • Subjective cognitive concerns (SCCs) are early indicators of dementia risk.
  • Understanding these links in African populations is vital for culturally relevant interventions.

Purpose of the Study:

  • To investigate the associations between psychological distress, SCCs, and clinical health markers in African adults.
  • To explore the role of demographic factors in these relationships.

Main Methods:

  • Analysis of baseline data from 145 adults (≥35 years) in the Brain Resilience Kenya study.
  • Assessment of psychological distress (PHQ-9, GAD-7) and SCCs via self-report.
  • Measurement of clinical biomarkers including glucose, lipids, creatinine, liver, and thyroid function.

Main Results:

  • Depressive symptoms correlated with cholesterol/HDL ratio and non-HDL cholesterol.
  • SCCs were linked to depressive symptoms, creatinine, and AST levels.
  • Associations between SCCs and clinical markers diminished after adjusting for age and gender.

Conclusions:

  • Mental health must be addressed in dementia prevention strategies.
  • Demographic factors significantly influence the relationship between psychological distress, SCCs, and clinical markers.
  • Further longitudinal research is needed to understand dementia risk and develop targeted interventions for African populations.