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Clinical Manifestations.

Howard Chertkow1

  • 1Rotman Research Institute, Baycrest Health Sciences, Toronto, ON, Canada.

Alzheimer'S & Dementia : the Journal of the Alzheimer'S Association
|December 25, 2025
PubMed
Summary
This summary is machine-generated.

New diagnostic criteria for Alzheimer Syndrome (AS) are proposed, distinguishing patients with and without motor features and predicting amyloid presence using clinical markers. This approach supports clinicians lacking biomarker access.

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Area of Science:

  • Neurology
  • Biomarkers
  • Clinical Diagnosis

Background:

  • Critiques a proposed AD diagnostic framework that overemphasizes biomarkers.
  • Highlights the negative impact of biomarker-centric diagnosis on clinicians and patients without biomarker access.
  • Emphasizes the value of clinical acumen in neurological diagnosis.

Purpose of the Study:

  • To propose revised diagnostic terminology and algorithms for Alzheimer's disease (AD).
  • To empower clinicians lacking direct biomarker access.
  • To improve diagnostic accuracy and differentiation in dementia patients.

Main Methods:

  • Literature review on clinical diagnosis of dementia.
  • Database review of 52 subjects with probable AD and known amyloid status.
  • Analysis of 145 subjects from the Canadian COMPASS-ND dataset with known amyloid status.

Main Results:

  • Proposes distinguishing dementia patients by presence or absence of motor features.
  • Introduces

Conclusions:

  • Advocates for terminology changes to incorporate biomarker-accessible language without disempowering clinicians.
  • Suggests accessible clinical markers can achieve good accuracy in predicting amyloid presence.
  • Recommends further research and replication across diverse global populations.