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Basic Science and Pathogenesis.

Naemah Md Hamzah1,2, Siong Meng Lim1,2, Fei Tieng Lim1

  • 1Faculty of Pharmacy, Universiti Teknologi MARA, Puncak Alam, Selangor, Malaysia.

Alzheimer'S & Dementia : the Journal of the Alzheimer'S Association
|December 25, 2025
PubMed
Summary
This summary is machine-generated.

Glial cells are present near lesion sites in zebrafish brains following 6-OHDA-induced dopaminergic neuron loss. These cells may guide the migration of newly regenerated neurons, offering insights into brain self-repair mechanisms for neurodegenerative diseases.

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Area of Science:

  • Neuroscience
  • Regenerative Medicine
  • Zebrafish Models

Background:

  • Neurodegenerative diseases lack treatments that halt progression, necessitating novel therapeutic strategies like promoting brain self-repair.
  • Mammalian models are limited for studying neuroregeneration due to inefficient self-repair.
  • Adult zebrafish, with brain homology to humans and self-renewal capabilities, are valuable models for neuroregeneration research.

Purpose of the Study:

  • To investigate the potential involvement of glial cells in facilitating the migration of newly regenerated dopaminergic neurons (DpN).
  • To examine glial cell expression and localization following 6-OHDA-induced lesions in adult zebrafish.

Main Methods:

  • Whole-brain imaging was employed to assess glial cell expression (gfap, olig2, glula) at 14 days post-lesion.
  • Immunohistochemistry (IHC) was performed on the most significantly expressed marker to analyze glial cell presence and location at 5, 7, and 14 days post-lesion.

Main Results:

  • A significantly higher number of gfap-immunoreactive cells were observed in the ventral diencephalon (vDn) and adjacent telencephalon at 14 days post-lesion.
  • IHC analysis confirmed the presence of glial cells in the preoptic area (POA), a region adjacent to the vDn lesion site.

Conclusions:

  • Glial cells are present near the POA and vDn lesion site 14 days post-6-OHDA lesion in adult zebrafish.
  • These findings suggest a potential role for glial cells in guiding neuronal migration during neuroregeneration.
  • Further research is warranted to elucidate the specific roles of glial cells in facilitating dopaminergic neuron regeneration.