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Preclinical Development: Overview

Preclinical Development: Overview

Preclinical development consists of a series of tests that ensure the safety and efficacy of a new therapeutic compound before it is tested in humans. There are four main phases to this process. First, safety pharmacology tests are conducted to ensure the drug does not produce any acutely harmful effects. These tests examine parameters such as bronchoconstriction, cardiac dysrhythmias, blood pressure changes, and ataxia. Next, preliminary toxicological testing is performed to determine the...

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Drug Regulation

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Drug regulation encompasses the management of drug usage by evaluating its safety and efficacy through assessments conducted by regulatory authorities. Regrettably, the history of drug regulation is marred by several catastrophic events. One such incident is the Elixir Sulfanilamide tragedy, in which the toxic compound diethyl glycol was included in a sweet-tasting medication, leading to numerous fatalities. This event prompted the enactment of the Food, Drug, and Cosmetic Act in 1938. Under...

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Related Experiment Video

Updated: Jan 7, 2026

Drug Repurposing Hypothesis Generation Using the "RE:fine Drugs" System

Drug Repurposing Hypothesis Generation Using the "RE:fine Drugs" System

Published on: December 11, 2016

Drug Development.

Thomas Finnegan¹, Frances McFarland², Austin Baiardi²

¹Medscape Education, Newtown Square, PA, USA.

Alzheimer'S & Dementia : the Journal of the Alzheimer'S Association

|December 25, 2025

Summary

This summary is machine-generated.

A 30-minute online Continuing Medical Education (CME) video effectively improved knowledge and confidence in neurologists and primary care physicians (PCPs) regarding Alzheimer's disease (AD) biomarkers and anti-amyloid therapies (AATs). The program enhanced understanding of diagnostic accuracy and risk factors associated with AATs.

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Developmental Toxicity Assay Based on Real-Time Monitoring of Fibroblast Growth Factor Signal Disruption in Human Induced Pluripotent Stem Cells

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Last Updated: Jan 7, 2026

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In Vitro Three-Dimensional Sprouting Assay of Angiogenesis Using Mouse Embryonic Stem Cells for Vascular Disease Modeling and Drug Testing

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Developmental Toxicity Assay Based on Real-Time Monitoring of Fibroblast Growth Factor Signal Disruption in Human Induced Pluripotent Stem Cells

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Published on: October 10, 2025

Area of Science:

Neurology
Medical Education

Background:

Alzheimer's disease (AD) research has yielded disease-modifying treatments targeting pathological hallmarks.
Physicians often lack up-to-date knowledge on AD biomarkers and antibody-based therapies.
An online Continuing Medical Education (CME) program was created to address this knowledge gap using recent dementia conference data.

Purpose of the Study:

To evaluate the effectiveness of a 30-minute online CME video in educating neurologists and primary care physicians (PCPs) on AD biomarkers and therapeutics.
To assess improvements in physician knowledge and confidence regarding the application of new AD treatments and diagnostic tools.

Main Methods:

A chapterized 30-minute video presentation featuring dementia specialists reviewing 2024 conference data on AD biomarkers and therapeutics.
Pre- and post-intervention assessment using identical questions to measure educational effect.
Statistical analysis including paired samples t-test, McNemar's test, and Cohen's d to determine significance and effect size.

Main Results:

A moderate educational effect (Cohen's d = 0.77 for neurologists, 0.75 for PCPs) was observed.
Significant pre- vs. post-educational improvements in understanding AD diagnostic accuracy (biomarker vs. clinical diagnosis) and AAT-related risks.
Increased confidence in applying latest clinical data on approved anti-amyloid therapies (AATs) reported by 44% of neurologists and 48% of PCPs.

Conclusions:

A concise, CME-certified video program effectively enhanced physician knowledge on emerging AD data from a recent medical conference.
Online CME is a valuable tool for disseminating critical updates on Alzheimer's disease diagnostics and therapeutics.
Future CME initiatives should prioritize impactful data presented at medical conferences.