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Area of Science:

  • Neuroscience
  • Neurology
  • Clinical Trials

Background:

  • Alzheimer's Disease (AD) is characterized by default mode network (DMN) dysfunction.
  • Repetitive transcranial magnetic stimulation (rTMS) offers a potential therapeutic approach by targeting DMN hubs.
  • This study leverages existing clinical evidence and accessible equipment for rTMS in AD.

Purpose of the Study:

  • To assess the feasibility and tolerability of rTMS targeting the precuneus in mild to moderate Alzheimer's Clinical Syndrome.
  • To explore the short-term efficacy of rTMS on episodic memory.
  • To refine the study protocol and collect preliminary data on target engagement and biomarkers.

Main Methods:

  • A two-stage trial involving 54 participants with mild to moderate Alzheimer's Clinical Syndrome.
  • Stage 1: Open-label treatment for protocol refinement (5-10 participants).
  • Stage 2: Randomized, double-blind, sham-controlled trial with 16 rTMS sessions over 5 weeks, assessing tolerability, feasibility, and exploratory outcomes including EEG, neuroimaging, and biomarkers.

Main Results:

  • Anticipated positive outcomes include treatment feasibility and tolerability.
  • Preliminary open-label data will be presented.
  • Evidence of target engagement and potential clinical improvement is expected.

Conclusions:

  • Positive feasibility and tolerability data will support further research into rTMS for AD.
  • Future studies will focus on demonstrating clinical efficacy and biomarker engagement.
  • Enhancing generalizability and scalability of the rTMS protocol is a long-term goal.