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Clinical Manifestations.

Agustin Perez1, Gaston Moreno Milicich2, Waleska Berrios3

  • 1Hospital Italiano de Buenos Aires, Buenos Aires, Argentina.

Alzheimer'S & Dementia : the Journal of the Alzheimer'S Association
|December 25, 2025
PubMed
Summary
This summary is machine-generated.

Behavioral variant frontotemporal dementia (bvFTD) is the most common subtype of frontotemporal spectrum disorder (FTLD). This study highlights the importance of timely recognition and diagnosis of FTLD subtypes in Argentina.

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Area of Science:

  • Neuroscience
  • Neurology
  • Geriatrics

Background:

  • Frontotemporal spectrum disorder (FTLD) comprises neurodegenerative conditions affecting frontal and temporal lobes.
  • FTLD subtypes include behavioral variant frontotemporal dementia (bvFTD), primary progressive aphasias (PPA), and FTD-motor neuron disease (FTD-MND).
  • Sociodemographic data on FTLD is limited, particularly in regions like Argentina.

Purpose of the Study:

  • To evaluate the demographic and clinical characteristics of patients diagnosed with FTLD.
  • To analyze the prevalence of different FTLD subtypes in a single-center cohort.
  • To assess time to diagnosis and treatment patterns for FTLD patients.

Main Methods:

  • Retrospective analysis of 26 FTLD patients diagnosed between January 2010 and April 2024.
  • Classification into subtypes: bvFTD, non-fluent PPA (nfvPPA), semantic PPA (svPPA), progressive supranuclear palsy/corticobasal syndrome (PSP/CBS), and FTD-MND.
  • Data collected included demographics, diagnosis time, family history, and medications.

Main Results:

  • bvFTD was the most prevalent subtype (42.3%), followed by nfvPPA and FTD-MND (19.2% each).
  • The sample was predominantly female (65.4%), with a mean age at diagnosis of 74.38 years.
  • Mean time to diagnosis was 2.04 years, with 34.6% treated with antipsychotics and 57.7% with antidepressants.

Conclusions:

  • bvFTD is the most frequent FTLD subtype, aligning with previous research.
  • A shorter diagnostic delay was observed compared to other reports, emphasizing the need for prompt recognition.
  • Future research should focus on expanding patient registries and assessing the socioeconomic impact of FTLD.