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Clinical Manifestations.

Esther Brill1, Alexa Frederike Holfelder1, Michael Falkner2

  • 1University Hospital of Old Age Psychiatry and Psychotherapy, Bern, Bern, Switzerland.

Alzheimer'S & Dementia : the Journal of the Alzheimer'S Association
|December 25, 2025
PubMed
Summary
This summary is machine-generated.

Computerized cognitive training (CCT) showed no short-term benefits for cognitive decline in older adults. High adherence suggests CCT may be valuable long-term or in combination with other interventions.

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Area of Science:

  • Neuroscience
  • Gerontology
  • Cognitive Psychology

Background:

  • Subjective cognitive decline (SCD) and Mild Cognitive Impairment (MCI) predict Alzheimer's Disease.
  • Computerized cognitive training (CCT) is a potential non-pharmacological intervention.
  • Previous CCT studies show mixed results and adherence challenges.

Purpose of the Study:

  • Evaluate CCT effectiveness in individuals with SCD/MCI.
  • Compare CCT against active and waitlist control groups.
  • Assess neurophysiological and blood-based biomarkers.

Main Methods:

  • Bi-centric randomized controlled trial (RCT) with 155 participants (mean age 72.2).
  • Three arms: CCT, active control (documentaries), waitlist control.
  • Three-month intervention with 60 sessions, followed by 6 months of CCT for the intervention group.

Main Results:

  • No significant group-by-timepoint interaction for cognitive outcomes.
  • High adherence (4.87 sessions/week) observed across groups.
  • No changes in grey matter volume or amyloid levels; subjective improvements noted after long-term training.

Conclusions:

  • Three-month CCT showed no specific cognitive or biological advantages.
  • High adherence indicates the importance of personalized, relevant interventions.
  • Long-term CCT showed positive subjective effects, suggesting its role in multicomponent interventions.