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Clinical Manifestations.

Alia Alokley1, Juan-Camilo Vargas-González1, Hessah A Alotibi1

  • 1Memory Clinic, Toronto Western Hospital, University Health Network, Toronto, ON, Canada.

Alzheimer'S & Dementia : the Journal of the Alzheimer'S Association
|December 25, 2025
PubMed
Summary
This summary is machine-generated.

Anxiety negatively impacts cognition in individuals with mild cognitive impairment, irrespective of amyloid-beta (Aβ) levels. This effect may be more pronounced in those without amyloid positivity.

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Area of Science:

  • Neuropsychology
  • Neurology
  • Biomarkers

Background:

  • Anxiety and depression are common in amnestic cognitive decline.
  • The influence of anxiety and depression on cognition, particularly concerning amyloid positivity (Aβ), remains under-examined in amnestic mild cognitive impairment (MCI).

Purpose of the Study:

  • To investigate the relationship between amyloid positivity (Aβ) and the effects of anxiety and depression on cognitive performance in patients with amnestic mild cognitive impairment.

Main Methods:

  • 67 patients with amnestic MCI underwent Positron Emission Tomography (PET) amyloid scans.
  • Anxiety and depression were assessed using the Neuropsychiatric Inventory Questionnaire (NPI-Q).
  • Cognition was evaluated using the Toronto Cognitive Assessment (TorCA), analyzed with TOBIT regression based on PET amyloid status.

Main Results:

  • Anxiety was found to significantly negatively affect overall cognition scores (p=0.042).
  • A trend suggested a greater negative impact of anxiety on cognition in PET amyloid-negative individuals (p=0.06) compared to PET amyloid-positive individuals (p=0.166).
  • Depression showed no significant association with cognitive score changes (p=0.34).

Conclusions:

  • Anxiety contributes to cognitive decline in individuals with amnestic mild cognitive impairment, irrespective of their PET amyloid status.
  • While not statistically significant, anxiety may exert a more substantial influence on cognition in amyloid-negative individuals.