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Clinical Manifestations.

Cassandra Sorin1, Natalie A Phillips1

  • 1Concordia University, Montreal, QC, Canada.

Alzheimer'S & Dementia : the Journal of the Alzheimer'S Association
|December 25, 2025
PubMed
Summary
This summary is machine-generated.

Older adults, including those with mild cognitive impairment (MCI) and dementia, reported low psychological distress during the COVID-19 pandemic. This resilience was observed across various cognitive profiles, contrary to expectations of increased vulnerability.

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Area of Science:

  • Gerontology
  • Neuroscience
  • Public Health

Background:

  • Older adults, particularly those with cognitive impairments, were presumed vulnerable to well-being decline during the COVID-19 pandemic.
  • Previous research often focused on the resilience of cognitively unimpaired older adults.
  • This study investigated pandemic experiences in a diverse group of Canadian older adults with varying cognitive statuses.

Purpose of the Study:

  • To assess the psychological well-being of Canadian community-dwelling older adults during the COVID-19 pandemic.
  • To compare pandemic-related distress across different cognitive profiles, including cognitively unimpaired, mild cognitive impairment (MCI), and dementia.
  • To explore the impact of cognitive status and sex on well-being during the pandemic.

Main Methods:

  • Utilized data from the Comprehensive Assessment of Neurodegeneration and Dementia (COMPASS-ND) Study.
  • Included participants with Cognitively Unimpaired (CU), Subjective Cognitive Decline (SCD), Parkinson's Disease (PD), Mild Cognitive Impairment (MCI), and Alzheimer's Disease (AD).
  • Administered questionnaires on COVID-19 experiences, including the Geriatric Depression Scale (GDS), Generalized Anxiety Disorder Scale (GAD-7), and Impact of Events Scale - Revised (IES-R).

Main Results:

  • Preliminary analysis indicated higher depression scores (GDS) for females and in diagnostic groups with cognitive impairment (MCI, AD, PD) compared to cognitively unimpaired (CU) individuals.
  • Anxiety scores (GAD-7) were higher in females but did not significantly differ across diagnostic groups.
  • No statistically significant differences in stress and trauma-related behaviors (IES-R) were found based on diagnostic group or sex.

Conclusions:

  • Contrary to expectations, the study sample reported relatively low levels of pandemic-related psychological distress across all cognitive profiles.
  • Findings suggest a degree of resilience in older adults, irrespective of cognitive functioning, during the COVID-19 pandemic.
  • Further research will integrate qualitative data, physical activity, and social support to provide a comprehensive understanding.