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Clinical Manifestations.

Neus Falgàs1, Nick Corriveau-Lecavalier2

  • 1Unitat d'Alzheimer i Altres Trastorns Cognitius, Servei de Neurologia, Hospital Clínic, Barcelona, Spain.

Alzheimer'S & Dementia : the Journal of the Alzheimer'S Association
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PubMed
Summary
This summary is machine-generated.

Atypical Alzheimer's disease (AD) variants, often with early non-memory symptoms, are underrepresented in clinical trials. New strategies are needed for inclusive research and equitable patient outcomes.

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Area of Science:

  • Neurology
  • Neuroscience
  • Clinical Research

Background:

  • Atypical Alzheimer's disease (AD) encompasses variants like PCA, lvPPA, dAD, and bvAD.
  • These variants present with early-onset and non-memory symptoms, leading to underrepresentation in trials.
  • Current AD therapies primarily target typical amnestic, late-onset AD.

Purpose of the Study:

  • To highlight the need for inclusive clinical trial designs for atypical AD.
  • To identify shortcomings in current trial designs for these patient populations.
  • To propose strategies for improving research and outcomes in atypical AD.

Main Methods:

  • Review of atypical AD features and current clinical trial limitations.
  • Analysis of enrollment strategies, endpoint development, and advocacy needs.
  • Discussion of recent amyloid-targeting therapies and their limited scope.

Main Results:

  • Atypical AD variants are significantly underrepresented in large-scale clinical trials.
  • Existing trial designs and therapies largely exclude patients with non-typical AD presentations.
  • Critical gaps exist in enrollment, outcome measures, and diagnostic accuracy for atypical AD.

Conclusions:

  • Urgent need for inclusive research for the full spectrum of AD.
  • Development of syndrome-specific endpoints and optimized enrollment is crucial.
  • Advocacy is essential for accurate diagnosis, equitable representation, and improved outcomes.