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Clinical Manifestations.

Pan-Woo Ko1

  • 1School of Medicine, Kyungpook National University, Daegu, DAEGU, Korea, Republic of (South).

Alzheimer'S & Dementia : the Journal of the Alzheimer'S Association
|December 25, 2025
PubMed
Summary
This summary is machine-generated.

Artificial intelligence (AI) tools like ChatGPT show promise in diagnosing degenerative diseases, accurately identifying final diagnoses in 77.8% of cases. This suggests AI can aid clinicians in dementia care and diagnosis.

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Area of Science:

  • Medical Artificial Intelligence
  • Neurology
  • Cognitive Science

Background:

  • Artificial intelligence (AI) tools are increasingly evaluated for medical applications.
  • Previous studies showed varied performance of ChatGPT on neurology exams.
  • This study focuses on AI performance in degenerative diseases.

Purpose of the Study:

  • To evaluate the clinical performance of ChatGPT (version 3.5) in diagnosing degenerative diseases.
  • To assess AI's ability to generate differential diagnoses and suggest diagnostic methods.
  • To determine AI's accuracy in providing final diagnoses based on case reports.

Main Methods:

  • Utilized nine case reports from 'Dementia and Neurocognitive Disorders' (2022-2024).
  • Input patient symptoms, history, and exam findings for differential diagnoses and methods.
  • Input test results for final diagnosis assessment.
  • Employed ChatGPT version 3.5 for all evaluations.

Main Results:

  • ChatGPT included the correct diagnosis in 33.3% of initial differential diagnoses.
  • AI suggested appropriate diagnostic methods in 88.9% of cases.
  • ChatGPT accurately identified the final diagnosis in 77.8% of cases after receiving test results.

Conclusions:

  • AI tools like ChatGPT demonstrate strong performance in clinical tasks related to dementia diagnosis.
  • AI shows potential in assisting with differential diagnoses and identifying appropriate diagnostic methods.
  • Advancements in AI technology offer promising applications in the field of dementia.