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Clinical Manifestations.

Kevin Duff1,2, Jace B King3, John M Hoffman4

  • 1Oregon Health & Science University, Portland, OR, USA.

Alzheimer'S & Dementia : the Journal of the Alzheimer'S Association
|December 25, 2025
PubMed
Summary
This summary is machine-generated.

Short-term practice effects (STPE) may indicate Alzheimer's disease (AD) biomarker positivity in individuals with subjective cognitive decline (SCD). This finding could help enrich clinical trials for AD.

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Area of Science:

  • Neuroscience
  • Biomarkers
  • Alzheimer's Disease Research

Background:

  • Subjective cognitive decline (SCD) may be an early sign of preclinical Alzheimer's disease (AD).
  • Individuals with SCD are a diverse group with various underlying causes.
  • Prior research explored short-term practice effects (STPE) in Mild Cognitive Impairment (MCI) and AD.

Purpose of the Study:

  • To investigate if STPE in individuals with SCD are associated with Alzheimer's disease (AD) biomarkers.
  • To determine if STPE can differentiate between individuals with and without cognitive complaints.

Main Methods:

  • 75 cognitively unimpaired participants were divided into SCD (n=11) and cognitively normal (CN, n=64) groups.
  • Participants completed a cognitive battery twice within a week to assess STPE.
  • Biomarker analysis included APOE genotyping, MRI for hippocampal volumes, and amyloid PET scans.

Main Results:

  • Greater number of APOE ε4 alleles correlated with smaller STPE in SCD individuals (r=-.42).
  • Larger hippocampal volumes were associated with larger STPE (r=0.25).
  • 73% of SCD participants were amyloid-positive compared to 19% of CN participants (p < 0.001).

Conclusions:

  • STPE were associated with AD biomarkers in individuals with SCD, mirroring findings in MCI and AD.
  • STPE may serve as an indicator of biomarker positivity in SCD.
  • STPE could potentially be a cost-effective tool for enriching AD clinical trials.