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Related Concept Videos

Blood Studies for Cardiovascular System I: Cardiac Biomarkers01:20

Blood Studies for Cardiovascular System I: Cardiac Biomarkers

746
Cardiac biomarkers are enzymes, proteins, and hormones released into the blood when cardiac cells are injured. They are powerful tools for triaging.
The essential diagnostic tools for detecting myocardial necrosis and monitoring individuals suspected of having acute coronary syndrome (ACS) include:
Troponins
Troponins, particularly cardiac troponins I and T, are the most precise and sensitive markers of myocardial injury. They are detectable within 4-6 hours of myocardial injury and remain...
746
Blood Studies for Cardiovascular System II: CRP, Hcy, and Cardiac Natriuretic Peptide Markers01:19

Blood Studies for Cardiovascular System II: CRP, Hcy, and Cardiac Natriuretic Peptide Markers

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Cardiac biomarkers are critical in diagnosing, prognosing, and managing cardiovascular diseases. Routine measurement of specific biomarkers such as B-type natriuretic peptide (BNP), C-reactive protein (CRP), and homocysteine (Hcy) is common practice in clinical settings to evaluate heart function and predict cardiovascular events.
These markers indicate stress or strain on the heart muscle:
Natriuretic Peptides (BNP)
Cardiac myocytes produce these hormones in response to ventricular stretching...
511

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Dried Blood Spot Collection of Health Biomarkers to Maximize Participation in Population Studies
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Biomarkers.

Marwan N Sabbagh1, Daryl Jones2, Jo Vandercappellen2

  • 1Barrow Neurological Institute, Phoenix, AZ, USA.

Alzheimer'S & Dementia : the Journal of the Alzheimer'S Association
|December 25, 2025
PubMed
Summary
This summary is machine-generated.

Accurate Alzheimer's disease diagnosis is crucial for new therapies. This study compares blood-based biomarkers (BBMs) against standard care, evaluating diagnostic timelines and patient journeys for dementia confirmation.

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Area of Science:

  • Neurology
  • Biomarker Discovery
  • Diagnostic Medicine

Background:

  • High rates of undetected dementia globally necessitate timely diagnosis for effective Alzheimer's disease (AD) treatment.
  • Emerging blood-based biomarkers (BBMs) show promise for accurate amyloid pathology confirmation, meeting stringent performance criteria.
  • This study addresses the need for efficient diagnostic pathways in the era of new anti-amyloid therapies.

Purpose of the Study:

  • To analyze the time to final biomarker-confirmed diagnosis using both novel BBMs and current standard of care (SOC) biomarkers.
  • To evaluate the reach and representativeness of patients receiving a BBM-confirmed diagnosis within a 6-month period.
  • To assess the number of patient visits required for diagnosis via different testing modalities.

Main Methods:

  • Prospective observational study collecting secondary data from electronic medical records across three US sites.
  • Recruitment of up to 180 patients aged ≥55 with suspected or possible AD and progressive cognitive decline.
  • Descriptive analysis of cognitive assessments, laboratory tests, imaging, patient characteristics, diagnostic procedures, and adverse events.

Main Results:

  • Three memory care clinics have been recruited, with plans to enroll up to 180 patients.
  • Data collection will include diagnostic test type, number of visits, time to diagnosis, and adverse events.
  • The study is designed as a descriptive analysis to characterize the diagnostic process.

Conclusions:

  • The study will delineate the time to final biomarker-confirmed diagnosis for both BBMs and current SOC biomarkers.
  • Findings will illuminate the patient diagnostic journey for Alzheimer's disease, potentially showcasing BBM benefits.
  • This research supports the evolving landscape of AD diagnostics, emphasizing accessible and scalable biomarker solutions.