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Clinical Manifestations.

Sarah Prieto1,2, Molly Split1, Alyssa N De Vito3,4

  • 1Alpert Medical School of Brown University, Providence, RI, USA.

Alzheimer'S & Dementia : the Journal of the Alzheimer'S Association
|December 25, 2025
PubMed
Summary
This summary is machine-generated.

Daily stress fluctuations impact cognitive performance in older adults. Higher stress improved visual working memory, especially in amyloid-beta positive individuals, while slowing processing speed.

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Area of Science:

  • Cognitive neuroscience
  • Gerontology
  • Psychology

Background:

  • Traditional research links stress and cognitive dysfunction in older adults using between-group comparisons.
  • Smartphone-based assessments enable within-person variability analysis of stress and cognition.
  • Amyloid-beta (Aβ) status may influence stress-cognition relationships.

Purpose of the Study:

  • To investigate within-person variability in stress as a predictor of cognitive outcomes.
  • To examine how stress-cognition associations differ based on amyloid-beta (Aβ) status.

Main Methods:

  • 123 cognitively normal adults (60-81 years) completed daily smartphone-based cognitive tasks (processing speed, visual working memory, episodic memory) over eight days.
  • Participants reported stress levels immediately before each cognitive assessment via the M2C2 app.
  • Multilevel modeling analyzed the interaction between within-person stress and session number, with exploratory analyses stratified by Aβ PET imaging results.

Main Results:

  • Lower stress was associated with quicker processing speed (PS) over time (p=.01).
  • Higher stress was linked to a more pronounced positive association between session number and visual working memory (WM) accuracy (p=.04).
  • Among amyloid-beta positive (Aβ+) individuals, higher stress interacted with session number to improve WM accuracy (p=.02).

Conclusions:

  • Intraindividual stress fluctuations significantly affect cognitive performance during remote monitoring.
  • Increased stress may impair processing speed but enhance visual working memory, particularly in Aβ+ individuals.
  • Stress-induced attentional resource changes might explain cognitive performance variations in specific domains.