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Clinical Manifestations.

Gregory Brown1,2, Diego Bustamante-Paytan1, Maria Fe Albujar-Pereira1

  • 1Instituto Peruano de Neurociencias, Lima, Lima, Peru.

Alzheimer'S & Dementia : the Journal of the Alzheimer'S Association
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Summary
This summary is machine-generated.

This study provides the first demographically adjusted cognitive norms for Peruvian adults using the Uniform Data Set (UDS) neuropsychological battery. These findings are crucial for accurate Alzheimer's disease diagnosis in diverse populations.

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Area of Science:

  • Neuroscience
  • Cognitive Psychology
  • Gerontology

Background:

  • Accurate Alzheimer's disease diagnosis relies on validated neuropsychological assessments with demographically adjusted norms.
  • The Uniform Data Set (UDS) is a standard multi-domain assessment for dementia detection but lacks validation in low-education populations.
  • Peru's population, with varying education levels, requires culturally appropriate cognitive assessment tools.

Purpose of the Study:

  • To establish demographically stratified normative cognitive data for Peruvian adults aged 43-79.
  • To validate the Uniform Data Set (UDS) neuropsychological battery for a Peruvian population, considering education levels.
  • To identify the influence of age and education on cognitive performance in Peru.

Main Methods:

  • Recruited 340 healthy Peruvian adults (ages 43-79), stratified by education (low: 0-6 years; high: ≥7 years).
  • Administered the UDS neuropsychological battery, including tests of memory, processing speed, and executive function.
  • Generated normative values using linear regression, controlling for age, education, and sex.

Main Results:

  • Education was the primary factor influencing performance across most UDS measures, except semantic fluency (vegetables).
  • Age was the second most significant predictor for 68% of the assessments.
  • Low education significantly impacted backward digit span, trail making, image naming, phonemic fluency, figure copy, and story recall.

Conclusions:

  • This study presents the first comprehensive, demographically stratified normative cognitive data for Peruvian adults (43-79 years).
  • The generated normative data are applicable across all education levels in the studied Peruvian population.
  • Culturally appropriate normative data are essential for the early and accurate detection of cognitive impairments, particularly in diverse linguistic and educational contexts.