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Dried Blood Spot Collection of Health Biomarkers to Maximize Participation in Population Studies
Published on: January 28, 2014
Biomarkers.
Hye Joo Son1,2, Jae Seung Kim3,4, Seonok Kim5
1Department of Nuclear Medicine, Dankook University College of Medicine, Cheonan, Chungnam, Korea, Republic of (South).
Genetic and lifestyle factors influence Alzheimer's disease trajectories. Physical activity and genetic mutations impact resistance to pathology, while openness to experience and living arrangements influence resilience, slowing neurodegeneration and cognitive decline in Autosomal Dominant Alzheimer's Disease (ADAD).
Area of Science:
- Neuroscience
- Genetics
- Gerontology
Background:
- Investigating interindividual variability in Alzheimer's disease trajectories.
- Focusing on resistance (slower pathological accumulation) and resilience (slower neurodegeneration despite pathology) in Autosomal Dominant Alzheimer's Disease (ADAD).
Purpose of the Study:
- To explore how genetic and modifiable lifestyle factors influence resistance and resilience in ADAD.
- To understand the distinct contributions of genetics and lifestyle to ADAD progression.
Main Methods:
- Analysis of longitudinal data from 189 ADAD carriers in the Dominantly Inherited Alzheimer Network cohort.
- Utilizing linear mixed-effects models and group-based trajectory modeling (GBTM) for clinical, CSF, imaging, and lifestyle assessments.
- Modeling pathological stages and tracking neurodegeneration and cognitive decline.
Main Results:
- Identified distinct trajectories for CSF p-tau181 and Aβ1-42, with high-resistance groups associated with APOE4, family mutation, and exercise.
- High-resilience group (FDG[precuneus]) showed slower hippocampal volume and CDR-SOB decline, linked to openness to experience.
- Low-resilience group (FDG[AD signature]) was more likely to live with others.
Conclusions:
- Longitudinal pathological accumulation in ADAD varies significantly, influenced by resistance factors.
- Resilience, characterized by slower functional neurodegeneration and cognitive decline, is associated with modifiable lifestyle factors.
- Distinct genetic and lifestyle factors contribute to resistance and resilience in ADAD, offering potential intervention targets.
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