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Blood Studies for Cardiovascular System I: Cardiac Biomarkers

Blood Studies for Cardiovascular System I: Cardiac Biomarkers

Cardiac biomarkers are enzymes, proteins, and hormones released into the blood when cardiac cells are injured. They are powerful tools for triaging.
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Biomarkers.

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Biomarkers.

Related Experiment Video

Dried Blood Spot Collection of Health Biomarkers to Maximize Participation in Population Studies

Dried Blood Spot Collection of Health Biomarkers to Maximize Participation in Population Studies

Published on: January 28, 2014

Biomarkers.

Hye Joo Son^1,2, Jae Seung Kim^3,4, Seonok Kim⁵

¹Department of Nuclear Medicine, Dankook University College of Medicine, Cheonan, Chungnam, Korea, Republic of (South).

Alzheimer'S & Dementia : the Journal of the Alzheimer'S Association

|December 25, 2025

View abstract on PubMed

Summary

This summary is machine-generated.

Genetic and lifestyle factors influence Alzheimer's disease trajectories. Physical activity and genetic mutations impact resistance to pathology, while openness to experience and living arrangements influence resilience, slowing neurodegeneration and cognitive decline in Autosomal Dominant Alzheimer's Disease (ADAD).

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Area of Science:

Neuroscience
Genetics
Gerontology

Background:

Investigating interindividual variability in Alzheimer's disease trajectories.
Focusing on resistance (slower pathological accumulation) and resilience (slower neurodegeneration despite pathology) in Autosomal Dominant Alzheimer's Disease (ADAD).

Purpose of the Study:

To explore how genetic and modifiable lifestyle factors influence resistance and resilience in ADAD.
To understand the distinct contributions of genetics and lifestyle to ADAD progression.

Main Methods:

Analysis of longitudinal data from 189 ADAD carriers in the Dominantly Inherited Alzheimer Network cohort.
Utilizing linear mixed-effects models and group-based trajectory modeling (GBTM) for clinical, CSF, imaging, and lifestyle assessments.
Modeling pathological stages and tracking neurodegeneration and cognitive decline.

Main Results:

Identified distinct trajectories for CSF p-tau181 and Aβ1-42, with high-resistance groups associated with APOE4, family mutation, and exercise.
High-resilience group (FDG[precuneus]) showed slower hippocampal volume and CDR-SOB decline, linked to openness to experience.
Low-resilience group (FDG[AD signature]) was more likely to live with others.

Conclusions:

Longitudinal pathological accumulation in ADAD varies significantly, influenced by resistance factors.
Resilience, characterized by slower functional neurodegeneration and cognitive decline, is associated with modifiable lifestyle factors.
Distinct genetic and lifestyle factors contribute to resistance and resilience in ADAD, offering potential intervention targets.