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Blood Studies for Cardiovascular System I: Cardiac Biomarkers01:20

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Cardiac biomarkers are enzymes, proteins, and hormones released into the blood when cardiac cells are injured. They are powerful tools for triaging.
The essential diagnostic tools for detecting myocardial necrosis and monitoring individuals suspected of having acute coronary syndrome (ACS) include:
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Cardiac biomarkers are critical in diagnosing, prognosing, and managing cardiovascular diseases. Routine measurement of specific biomarkers such as B-type natriuretic peptide (BNP), C-reactive protein (CRP), and homocysteine (Hcy) is common practice in clinical settings to evaluate heart function and predict cardiovascular events.
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Dried Blood Spot Collection of Health Biomarkers to Maximize Participation in Population Studies
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Biomarkers.

Felix Carbonell1, Carolann McNicoll1, Alex P Zijdenbos1

  • 1Biospective Inc., Montreal, QC, Canada.

Alzheimer'S & Dementia : the Journal of the Alzheimer'S Association
|December 25, 2025
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Summary
This summary is machine-generated.

Tau PET scores correlate with brain atrophy in mild cognitive impairment (MCI). These findings suggest tau pathology drives neurodegeneration independently of beta-amyloid, impacting gray matter density and cortical thickness.

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Area of Science:

  • Neuroimaging
  • Biomarkers
  • Neurodegeneration

Background:

  • Tau PET imaging shows correlation with cortical thickness and glucose metabolism in MCI.
  • Hypothesis: Tau PET scores associate with gray matter density, independent of beta-amyloid and APOE e4.

Purpose of the Study:

  • Investigate the association between Tau PET scores and atrophy biomarkers in MCI.
  • Determine if this association is independent of beta-amyloid and APOE e4.

Main Methods:

  • Cross-sectional analysis of Tau PET, Amyloid PET, and MRI data from 222 MCI subjects.
  • Derived atrophy biomarkers: cortical thickness, relative and absolute gray matter density.
  • Used Singular Value Decomposition (SVD) to assess tau's effect on atrophy, controlling for beta-amyloid.

Main Results:

  • Tau PET scores showed significant associations with cortical thickness, relative GM density, and absolute GM density.
  • SVD components explained substantial co-variability between tau PET and atrophy measures.
  • Statistical maps confirmed tau's effect on cortical thickness and GM density, independent of beta-amyloid.

Conclusions:

  • Distributed tau scores correlate with consistent atrophy patterns in MCI.
  • Tau pathology is linked to gray matter reductions, independent of beta-amyloid burden.
  • Tau plays a significant role in neurodegeneration in MCI.