Biomarkers
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View abstract on PubMed
Summary
This summary is machine-generated.Sex differences in brain volume change with age. Female sex is linked to smaller occipital and larger ventricular volumes in younger adults, but these associations disappear in older age groups.
Area Of Science
- Neuroimaging
- Gerontology
- Neurodegeneration
Background
- Sex differences in aging and dementia-related neurodegeneration are not fully understood across the lifespan.
- Investigating how sex influences brain structure changes over time is crucial for understanding age-related cognitive decline.
Purpose Of The Study
- To examine sex differences in brain region volumes across different age groups.
- To determine if the association between sex and brain structure varies with age.
Main Methods
- Utilized 3T MRI data from 838 racially and ethnically diverse older adults (346 male, 492 female).
- Analyzed total cortical gray matter, hippocampus, ventricular, frontal, occipital, parietal, and temporal lobe volumes.
- Employed linear regression models and age-stratified analyses (50-74, 75-89, 90+ years) to assess sex-specific effects.
Main Results
- Female sex was associated with smaller occipital and larger ventricular volumes in adults aged 50-74.
- These associations were not significant in older age groups (75-89 and 90+).
- For individuals aged 90+, the direction of association for occipital and ventricular volumes differed compared to the younger group.
Conclusions
- The relationship between sex and brain region volume is age-dependent.
- Female sex is associated with specific brain volume differences (occipital, ventricular) in younger older adults, but not in the oldest age groups.
- Further research is needed to understand the mechanisms driving these sex-by-age interactions and their impact on cognition.
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