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Related Concept Videos

Blood Studies for Cardiovascular System I: Cardiac Biomarkers01:20

Blood Studies for Cardiovascular System I: Cardiac Biomarkers

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Cardiac biomarkers are enzymes, proteins, and hormones released into the blood when cardiac cells are injured. They are powerful tools for triaging.
The essential diagnostic tools for detecting myocardial necrosis and monitoring individuals suspected of having acute coronary syndrome (ACS) include:
Troponins
Troponins, particularly cardiac troponins I and T, are the most precise and sensitive markers of myocardial injury. They are detectable within 4-6 hours of myocardial injury and remain...
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Blood Studies for Cardiovascular System II: CRP, Hcy, and Cardiac Natriuretic Peptide Markers01:19

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Cardiac biomarkers are critical in diagnosing, prognosing, and managing cardiovascular diseases. Routine measurement of specific biomarkers such as B-type natriuretic peptide (BNP), C-reactive protein (CRP), and homocysteine (Hcy) is common practice in clinical settings to evaluate heart function and predict cardiovascular events.
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Cardiac myocytes produce these hormones in response to ventricular stretching...
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Dried Blood Spot Collection of Health Biomarkers to Maximize Participation in Population Studies
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Biomarkers.

Xiaoli Hao1, Xuan Yang1, Lu Shen1

  • 1Xiangya Hospital, Central South University, Changsha, Hunan, China.

Alzheimer'S & Dementia : the Journal of the Alzheimer'S Association
|December 25, 2025
PubMed
Summary
This summary is machine-generated.

Surface electromyography (sEMG) effectively detects cognitive impairment (CI) by analyzing motor changes. Combining sEMG with plasma biomarkers significantly enhances CI and mild cognitive impairment (MCI) screening accuracy.

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Area of Science:

  • Neurology
  • Biomedical Engineering
  • Gerontology

Background:

  • Motor changes often precede cognitive impairment (CI).
  • Surface electromyography (sEMG) offers a non-invasive method for motor assessment.
  • The utility of sEMG in detecting CI requires further clarification.

Purpose of the Study:

  • To investigate the efficacy of sEMG in identifying individuals with cognitive impairment.
  • To explore the relationship between sEMG features, cognitive status, and plasma biomarkers.

Main Methods:

  • Enrolled 639 participants (284 CI, 355 controls) for motor and cognitive assessments.
  • Performed sEMG under single and dual-task conditions.
  • Measured plasma phosphorylated tau 181 (p-tau181) in a subset.

Main Results:

  • CI group showed significant deficits in motor functions like balance and gait.
  • 20 sEMG features differed significantly between CI patients and controls (p < 0.05).
  • A combined sEMG model achieved high AUCs (0.849 for CI, 0.875 for MCI), reaching 0.948 with p-tau181 for CI detection.

Conclusions:

  • Motor changes are consistently present in patients with CI.
  • sEMG demonstrates potential as an effective tool for cognitive impairment screening.