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Related Concept Videos

Blood Studies for Cardiovascular System I: Cardiac Biomarkers01:20

Blood Studies for Cardiovascular System I: Cardiac Biomarkers

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Cardiac biomarkers are enzymes, proteins, and hormones released into the blood when cardiac cells are injured. They are powerful tools for triaging.
The essential diagnostic tools for detecting myocardial necrosis and monitoring individuals suspected of having acute coronary syndrome (ACS) include:
Troponins
Troponins, particularly cardiac troponins I and T, are the most precise and sensitive markers of myocardial injury. They are detectable within 4-6 hours of myocardial injury and remain...
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Blood Studies for Cardiovascular System II: CRP, Hcy, and Cardiac Natriuretic Peptide Markers01:19

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Cardiac biomarkers are critical in diagnosing, prognosing, and managing cardiovascular diseases. Routine measurement of specific biomarkers such as B-type natriuretic peptide (BNP), C-reactive protein (CRP), and homocysteine (Hcy) is common practice in clinical settings to evaluate heart function and predict cardiovascular events.
These markers indicate stress or strain on the heart muscle:
Natriuretic Peptides (BNP)
Cardiac myocytes produce these hormones in response to ventricular stretching...
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Updated: Jan 7, 2026

Dried Blood Spot Collection of Health Biomarkers to Maximize Participation in Population Studies
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Biomarkers.

Xinyi Xia1, Xinyu Zhang2, Qi Qin1

  • 1Department of Neurology & Innovation Center for Neurological Disorders, Xuanwu Hospital, Capital Medical University, National Center for Neurological Disorders, Beijing, Beijing, China.

Alzheimer'S & Dementia : the Journal of the Alzheimer'S Association
|December 25, 2025
PubMed
Summary
This summary is machine-generated.

A novel 7-microRNA (miRNA) panel in serum shows high accuracy for diagnosing Alzheimer's disease (AD). This minimally invasive blood test correlates with cognitive decline and key AD biomarkers.

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Area of Science:

  • Biochemistry
  • Genetics
  • Neuroscience

Background:

  • MicroRNAs (miRNAs) are investigated as stable, blood-based biomarkers for Alzheimer's disease (AD).
  • miRNAs play regulatory roles in biological pathways implicated in AD pathogenesis.
  • This study focused on developing a diagnostic panel using serum miRNAs.

Purpose of the Study:

  • To develop and validate a serum-based microRNA (miRNA) panel for Alzheimer's disease (AD) diagnosis.
  • To assess the diagnostic accuracy of the miRNA panel in independent cohorts.
  • To evaluate the association of the miRNA panel with cognitive function and AD biomarkers.

Main Methods:

  • Serum samples from 474 participants (Alzheimer's disease and healthy controls) were analyzed across discovery, training, and validation cohorts.
  • A 7-miRNA signature was identified using small RNA sequencing and quantitative PCR (qPCR).
  • Machine learning models were employed to validate the diagnostic performance of the miRNA panel.

Main Results:

  • The 7-miRNA panel achieved high diagnostic accuracy, with an area under the curve (AUC) of 0.970 in the training cohort and 0.928 in the validation cohort.
  • A risk score derived from the panel significantly correlated with cognitive impairment (MMSE scores, r = -0.72).
  • The panel also showed significant associations with plasma amyloid pathology biomarkers, including Aβ42/40 ratio (r = -0.25) and p-tau217 (r = 0.36).

Conclusions:

  • The developed serum-based 7-miRNA panel demonstrates significant potential for accurate Alzheimer's disease diagnosis.
  • This approach offers a minimally invasive and accessible method for AD detection.
  • The findings support the utility of circulating miRNAs as valuable biomarkers in AD diagnostics.