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Clinical Manifestations.

Raphael Lopes Sartori1, Marcelo J Aureliano2, Vitor Tumas2

  • 1Faculty of Philosophy, Sciences, and Letters of the University of São Paulo, Ribeirão Preto, São Paulo, Brazil.

Alzheimer'S & Dementia : the Journal of the Alzheimer'S Association
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Summary
This summary is machine-generated.

Cognitive training combined with transcranial direct current stimulation (tDCS) improved working memory in Parkinson's disease patients. This intervention shows promise for managing cognitive decline in PD.

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Area of Science:

  • Neuroscience
  • Cognitive Science
  • Neurology

Background:

  • Parkinson's disease (PD) frequently involves cognitive symptoms preceding diagnosis.
  • Cognitive training (CT) shows potential for enhancing cognitive functions like working memory.
  • Combining CT with neuromodulation, such as transcranial direct current stimulation (tDCS), is an emerging therapeutic strategy for PD cognitive impairment.

Purpose of the Study:

  • To investigate the efficacy of combining cognitive training (CT) with transcranial direct current stimulation (tDCS) for improving cognitive functions in Parkinson's disease (PD) patients.
  • To evaluate the impact of anodal tDCS targeting the left dorsolateral prefrontal cortex when paired with a cognitive training task.
  • To assess changes in working memory, attention, mood, and overall cognition in PD patients undergoing the combined intervention.

Main Methods:

  • Twenty individuals diagnosed with PD (aged 50-80, no dementia) were randomized into active tDCS or placebo groups.
  • Both groups underwent cognitive training combined with tDCS (2 mA for 30 minutes over five sessions) targeting the left dorsolateral prefrontal cortex.
  • The Categorization Working Memory Span Task (CWMS) was used to measure improvements in working memory and attention, with assessments before and after the intervention.

Main Results:

  • Preliminary data indicated statistically significant improvements in Recall (p=0.030) and Tapping (p=0.038) performance on the CWMS task.
  • These improvements were observed irrespective of whether participants received active tDCS or placebo.
  • No significant changes were detected in mood or broader neuropsychological cognitive measures.

Conclusions:

  • The combination of cognitive training and tDCS demonstrates potential for enhancing specific working memory tasks in Parkinson's disease patients.
  • The findings suggest that CT, potentially augmented by tDCS, may help mitigate cognitive deficits in PD.
  • Further research with larger cohorts is warranted to confirm these preliminary results and explore the full therapeutic potential.