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Clinical Manifestations.

Jeanne Gallée1,2, Jade Cartwright3, Maya L Henry4

  • 1University of Washington School of Medicine, Seattle, WA, USA.

Alzheimer'S & Dementia : the Journal of the Alzheimer'S Association
|December 25, 2025
PubMed
Summary
This summary is machine-generated.

Researchers developed the Functional Communication Checklist (FCC) to quantify functional communication (FC) in primary progressive aphasia (PPA). This new tool aids in assessing communication abilities for individuals with PPA.

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Area of Science:

  • Neuroscience
  • Speech and Language Pathology

Background:

  • Functional communication (FC) is crucial for daily life and patient autonomy.
  • Quantitative measures for FC in neurodegenerative conditions, especially primary progressive aphasia (PPA), are lacking.
  • A minimally burdensome assessment tool is needed for PPA.

Purpose of the Study:

  • To develop the first instrument to document functional communication (FC) in individuals with PPA.
  • To create the Functional Communication Checklist (FCC) incorporating expert feedback and validation.

Main Methods:

  • Candidate FCC items were generated by PPA experts and refined by speech-language pathologists (SLPs) using an electronic Delphi consensus process.
  • SLPs were recruited through professional networks and publication records.
  • Feedback from Delphi rounds was used to refine the FCC, with planned evaluation of validity and inter-rater reliability.

Main Results:

  • 67 experts contributed to the FCC development.
  • The current FCC iteration assesses 55 aspects across discourse, social-pragmatics, language, speech, and cognition.
  • Each domain is evaluated on a spectrum of strength or interference in communication.

Conclusions:

  • The FCC quantifies FC by combining clinician observation, patient self-report, and partner insight.
  • Quantitative outcomes will establish a common FC taxonomy, promoting interdisciplinary collaboration and consistency.
  • The FCC development highlights the value of cross-disciplinary research partnerships.