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Related Concept Videos

Blood Studies for Cardiovascular System I: Cardiac Biomarkers01:20

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Cardiac biomarkers are enzymes, proteins, and hormones released into the blood when cardiac cells are injured. They are powerful tools for triaging.
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Cardiac biomarkers are critical in diagnosing, prognosing, and managing cardiovascular diseases. Routine measurement of specific biomarkers such as B-type natriuretic peptide (BNP), C-reactive protein (CRP), and homocysteine (Hcy) is common practice in clinical settings to evaluate heart function and predict cardiovascular events.
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Dried Blood Spot Collection of Health Biomarkers to Maximize Participation in Population Studies
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Biomarkers.

Michalis Kassinopoulos1, Aldana Lizarraga1, Mahnaz Shekari1

  • 1Barcelonaβeta Brain Research Center (BBRC), Pasqual Maragall Foundation, Barcelona, Spain.

Alzheimer'S & Dementia : the Journal of the Alzheimer'S Association
|December 25, 2025
PubMed
Summary
This summary is machine-generated.

Regional homogeneity (ReHo) may predict early Alzheimer's disease amyloid changes, offering a potential biomarker alongside fluorodeoxyglucose positron emission tomography (FDG-PET). This study explored ReHo's clinical utility in preclinical Alzheimer's disease.

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Area of Science:

  • Neuroimaging
  • Biomarker Discovery
  • Alzheimer's Disease Research

Background:

  • Regional homogeneity (ReHo) measures blood oxygen level-dependent (BOLD) signal coherence in resting-state functional MRI (rs-fMRI).
  • ReHo reflects brain activity and oxygen consumption, similar to FDG-PET.
  • The clinical utility of ReHo for predicting Alzheimer's disease (AD) pathology remains largely unexplored.

Purpose of the Study:

  • To assess the feasibility of using ReHo to predict changes in amyloid deposition in cognitively unimpaired individuals at high risk for AD.
  • To compare the performance of ReHo with FDG-PET in identifying early AD-related changes.

Main Methods:

  • 330 cognitively unimpaired individuals underwent rs-fMRI, FDG-PET, Aβ-PET, and CSF analysis (Aβ42/40, p-tau181).
  • ReHo and FDG measures were extracted and correlated with baseline and longitudinal changes in amyloid load.
  • Statistical models were adjusted for age, sex, APOE status, education, and p-tau181.

Main Results:

  • Cross-sectionally, lower ReHo correlated with lower CSF Aβ42/40, while FDG showed no significant association with amyloid.
  • Longitudinally, lower baseline FDG predicted increased PET amyloid burden over time.
  • Higher baseline ReHo predicted decreases in CSF Aβ42/40 over time.

Conclusions:

  • Baseline ReHo and FDG offer complementary information on amyloid dynamics in preclinical AD.
  • ReHo demonstrates potential as a predictive biomarker for early changes in soluble amyloid-beta (Aβ).
  • Further research is warranted to explore the clinical utility of ReHo alongside FDG-PET in AD.