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Blood Studies for Cardiovascular System I: Cardiac Biomarkers

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Dried Blood Spot Collection of Health Biomarkers to Maximize Participation in Population Studies

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Biomarkers.

Jannatun Namme¹, Yulong Xu², Changning Wang³

¹Virginia Commonwealth University, Richmond, VA, USA.

Alzheimer'S & Dementia : the Journal of the Alzheimer'S Association

|December 25, 2025

Summary

Researchers developed a novel PET radiotracer targeting mitochondrial complex I defects, crucial in Alzheimer's disease (AD) and related dementias (ADRD). This tracer shows promise for visualizing neurodegeneration in mouse models.

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Area of Science:

Neuroscience
Biochemistry
Radiochemistry

Background:

Mitochondrial dysfunction is implicated in Alzheimer's disease and related dementias (AD/ADRD).
Complex I defects in the electron transport chain (ETC) are linked to reactive oxygen species (ROS) production and neurodegeneration.

Purpose of the Study:

To synthesize and characterize novel mitochondrial complex I inhibitors as Positron Emission Tomography (PET) radiotracers.
To develop a PET imaging agent for visualizing complex I activity in the brain.

Main Methods:

Synthesis of novel mitochondrial complex I inhibitors.
Radiolabeling of an inhibitor with Fluorine-18 (F-18).
Characterization of the F-18 radiotracer in mice using PET/CT imaging for biodistribution and brain penetration.

Main Results:

The F-18 radiotracer demonstrated rapid brain entry and favorable clearance kinetics.
Blocking studies confirmed the specificity of the radiotracer for its target, mitochondrial complex I.

Conclusions:

A novel F-18 labeled PET radiotracer targeting mitochondrial complex I was successfully synthesized.
In vivo PET/CT studies in mice validated the radiotracer's potential for imaging brain complex I activity.